Results 1 to 10 of about 119 (69)
Neuroprotective Roles of the Biliverdin Reductase-a/Bilirubin Axis in the Brain
BiomoleculesBiliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in ...
Andrew A Pieper, Bindu D Paul
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EXCLI Journal : Experimental and Clinical Sciences, 2021 Biliverdin reductase, biliverdin and bilirubin are known as important components of cellular signaling pathways that play major roles in cell proliferation and apoptosis, although their physiological relevance is still under evaluation.
Seyedeh Zahra Shahrokhi +2 more
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Metabolic Functions of Biliverdin IXβ Reductase in Redox-Regulated Hematopoietic Cell Fate
Antioxidants, 2023 Cytoprotective heme oxygenases derivatize heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin.
Wadie F. Bahou +2 more
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Microorganisms, 2023 Oxygenic photosynthesis requires metal-rich cofactors and electron-transfer components that can produce reactive oxygen species (ROS) that are highly toxic to cyanobacterial cells. Biliverdin reductase (BvdR) reduces biliverdin IXα to bilirubin, which is
Wendy M. Schluchter +6 more
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Frontiers in Cellular Neuroscience, 2020 Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár +10 more
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Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua. [PDF]
PLoS ONE, 2014 The bilin-binding proteins (BBP) from lepidopteran insects are members of the lipocalin family of proteins and play a special role in pigmentation through the binding of biliverdin IXγ.
Ana B G Veiga +5 more
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Scalable production of biliverdin IXα by
BMC Biotechnology, 2012 Background Biliverdin IXα is produced when heme undergoes reductive ring cleavage at the α-methene bridge catalyzed by heme oxygenase. It is subsequently reduced by biliverdin reductase to bilirubin IXα which is a potent endogenous antioxidant ...
Chen Dong +4 more
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Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
Frontiers in Molecular Biosciences, 2021 The biliverdin reductase B (BLVRB) class of enzymes catalyze the NADPH-dependent reduction of multiple flavin substrates and are emerging as critical players in cellular redox regulation.
Jasmina S. Redzic +5 more
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Physiological antioxidative network of the bilirubin system in aging and age-related diseases
Frontiers in Pharmacology, 2012 Oxidative stress is detrimental to life processes and is particularly responsible for aging and age-related diseases. Thus, most organisms are well equipped with a spectrum of biological defense mechanisms against oxidative stress.
Sung Young eKim, Sang Chul ePark
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Direct antioxidant properties of bilirubin andbiliverdin. Is there a role for biliverdin reductase?
Frontiers in Pharmacology, 2012 Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of endothelial dysfunction and represent a major contribution to vascular regulation. Molecular signaling is highly dependent on reactive oxygen species. But depending on
Thomas eJansen, Andreas eDaiber
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