Results 31 to 40 of about 107,951 (150)

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares

Pediatric Rheumatology Online Journal, 2020
Background Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin.
Alice S. Chau, Bonnie L. Cole, Jason S. Debley, Kabita Nanda, Aaron B. I. Rosen, Michael J. Bamshad, Deborah A. Nickerson, Troy R. Torgerson, Eric J. Allenspach   +8 more
doaj   +1 more source

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Nature Communications, 2023
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes.
Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager   +8 more
doaj   +1 more source

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

, 2011
Biliverdin reductase-A is a pleiotropic enzyme involved not only in the reduction of biliverdin-IX-alpha into bilirubin-IX-alpha, but also in the regulation of glucose metabolism and cell growth secondary to its serine/threonine/tyrosine kinase activity.
CENINI G, SULTANA R, BUTTERFIELD DA, Sultana, Rukhsana, Cenini, Giovanna, Cesare Mancuso, PERLUIGI, Marzia, D. Allan Butterfield, Preziosi, Paolo, Marzia Perluigi, Barone, Eugenio, DI DOMENICO, FABIO, Butterfield, D. Allan, Paolo Preziosi, PREZIOSI P, Rukhsana Sultana, CINI, Chiara, Mancuso, Cesare, Fabio Di Domenico, Chiara Cini, MANCUSO C, Giovanna Cenini, Eugenio Barone   +22 more
core   +1 more source

Breakdown products of heme catabolism as senescence index in sea lamprey (Petromyzon marinus Linnaeus, 1758)

Frontiers in Marine Science, 2015
Biliverdin and bilirubin are breakdown products of normal heme catabolism, caused by the body's clearance of aged red blood cells which contain hemoglobin.
Sandra Barca, Sergio Silva, María José Servia   +2 more
doaj   +1 more source

Spectrophotometric Assessment of Heme Oxygenase-1 Activity in Leishmania-infected Macrophages

Bio-Protocol, 2020
Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL). Estimation of bilirubin is the basis of HO-1 assay.
Moumita Basu, Shriya Saha, Anindita Ukil
doaj   +1 more source

Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin

Antioxidants, 2022
Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective weight maintenance. Exercise boosts the production of reactive
David Travis Thomas, Nicholas R. DelCimmuto, Kyle D. Flack, David E. Stec, Terry D. Hinds   +4 more
doaj   +1 more source

Purification and Characterization of Human Biliverdin Reductase

Archives of Biochemistry and Biophysics, 1993
Conversion of biliverdin to bilirubin is catalyzed by the cytosolic enzyme biliverdin reductase. We have purified and characterized the human liver reductase and find it to differ extensively from the previously described rat enzyme (H. Fakhrai and M. D. Maines, 1992, J. Biol. Chem.
M D, Maines, G M, Trakshel
openaire   +2 more sources

ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity [PDF]

, 2021
Although the role of hydrophilic antioxidants in the development of hepatic insulin resistance and nonalcoholic fatty liver disease has been well studied, the role of lipophilic antioxidants remains poorly characterized.
Gharakhanian, Raffi, Segawa, Mayuko, Young, Margaret R, Adamson, Roslin, Nocito, Laura, Shum, Michael, Abramson, Jeff, Gutierrez, Vincent, Veliova, Michaela, Ngo, Jennifer, Su, Shi, Saxberg, Alexandra D, Stiles, Linsey, Althoff, Thorsten, Faust, Belinda, Mahdaviani, Kiana, Zoghbi, Maria E, Lusis, Aldons J, Liesa, Marc, Martinez, Melissa, Wolf, Dane M, Hevener, Andrea L, Chella Krishnan, Karthickeyan, Carpenter, Elisabeth P, Shintre, Chitra A, Shi Su, Michael Shum, Roslin Adamson, Jeff Abramson, Dane M. Wolf, Vincent Gutierrez, Kiana Mahdaviani, Michaela Veliova, Raffi Gharakhanian, Jennifer Ngo, Chitra A. Shintre, Elisabeth P. Carpenter, Melissa Martinez, Laura Nocito, Mayuko Segawa, Maria E. Zoghbi, Alexandra D. Saxberg, Linsey Stiles, Karthickeyan Chella Krishnan, Belinda Faust, Marc Liesa, Margaret R. Young, Thorsten Althoff, Andrea L. Hevener, Aldons J. Lusis   +49 more
core   +1 more source

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

Biomolecules, 2021
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella   +3 more
doaj   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source