Results 51 to 60 of about 107,951 (150)

Protein/Protein Interactions in the Mammalian Heme Degradation Pathway \u3ci\u3eHEME OXYGENASE-2, CYTOCHROME P450 REDUCTASE, AND BILIVERDIN REDUCTASE\u3c/i\u3e [PDF]

, 2014
Background: Heme oxygenase, cytochrome P450 reductase, and biliverdin reductase are the key enzymes in heme degradation. Results: Specific electrostatic and hydrophobic interactions form the binding interface between heme oxygenase and cytochrome P450 ...
Zuiderweg, Erik R. P., Bagai, Ireena, Becker, Donald F., Ragsdale, Stephen W., Spencer, Andrea L. M.   +4 more
core  

Sarcopenia Predicts Postoperative Cognitive Impairment and Poor Surgical Outcomes in Older Adults: A Prospective Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Sarcopenia is a progressive skeletal muscle disorder prevalent in older adults, yet its role as a risk factor for acute postoperative cognitive decline—an early manifestation within the spectrum of perioperative neurocognitive disorders (PND)—remains underexplored.
Xingming Tang, Yuncai Gu, Li Wang, Xiaochu Wu, Yipu Ren, Shudie Zhou, Yulong Cai, Xian Du, Xun Xia, Tianyao Zhang   +9 more
wiley   +1 more source

Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin

Antioxidants, 2020
Phytocannabinoids protect neurons against stressful conditions, possibly via the heme oxygenase (HO) system. In cultures of primary mesencephalic neurons and neuroblastoma cells, we determined the capability of cannabidiol (CBD) and tetrahydrocannabinol (
Johanna Catharina Duvigneau, Alice Trovato, Andrea Müllebner, Ingrid Miller, Christopher Krewenka, Kristina Krenn, Wilhelm Zich, Rudolf Moldzio   +7 more
doaj   +1 more source

Evidence that biliverdin-IXβ reductase and flavin reductase are identical [PDF]

Biochemical Journal, 1996
A search of the database shows that human biliverdin-IXβ reductase and flavin reductase are identical. We have isolated flavin reductase from bovine erythrocytes and show that the activity co-elutes with biliverdin-IXβ reductase. Preparations of the enzyme that are electrophoretically homogeneous exhibit both flavin reductase and biliverdin-IXβ ...
F, Shalloe, G, Elliott, O, Ennis, T J, Mantle   +3 more
openaire   +2 more sources

Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase

, 2008
BVR-B (biliverdin-IXbeta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone) and ferric ion. Mechanistically it
Mulholland, Adrian J, Mantle, Timothy J, Smith, Liam J, Browne, Seamus   +3 more
core   +1 more source

Mesobiliverdin-IXα Enhances Rat Pancreatic Islet Yield and Function

Frontiers in Pharmacology, 2013
The aims of this study were to produce mesobiliverdin IXα, an analog of anti-inflammatory biliverdin IXα and to test its ability to enhance rat pancreatic islet yield for allograft transplantation into diabetic recipients.
Taihei eIto, Dong eChen, Dong eChen, Cheng-Wei T. Chang, Cheng-Wei T. Chang, Takashi eKenmochi, Tomonori eSaito, Satoshi eSuzuki, Jon Y Takemoto, Jon Y Takemoto   +9 more
doaj   +1 more source

A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.
ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger, Nicolas Hebert, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Sandia Adypagavane, Meghan Perkins, Laura Matabishi‐Bibi, France Pirenne, Claire Berquet, Stephane Moutereau, Serge Pissard, Frédéric Galactéros, Michael C. Marden, Pablo Bartolucci   +14 more
wiley   +1 more source

Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha)

Molecules, 2021
Recent work has shown that bilirubin has a hormonal function by binding to the peroxisome proliferator-activated receptor-α (PPARα), a nuclear receptor that drives the transcription of genes to control adiposity.
Darren M. Gordon, Stephen H. Hong, Zachary A. Kipp, Terry D. Hinds   +3 more
doaj   +1 more source

Photophysical and Computational Exploration of Human Serum Albumin Mediated Sensing of Bilirubin via a D‐π‐A Probe

Chemistry–Methods, Volume 6, Issue 7, July 2026.
This work reports the efficacy of an ensemble‐based sensor, A3‐HSA, for selective bilirubin sensing. Experimental and computational studies showed that the strong binding of bilirubin to HSA facilitated the replacement of D‐π‐A probe A3 at the IB site of HSA.
Anamika Bandyopadhyay, Anupam Bhattacharya   +1 more
wiley   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source