Results 51 to 60 of about 183 (125)

Ferroptotic neurodegeneration and diet: a narrative review

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
Ximaine R. van der Burg, Danielle V. Toen, Scott Ayton, Hanno Pijl, Louise van der Weerd   +4 more
wiley   +1 more source

The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

Frontiers in Immunology, 2023
ObjectiveInflammation-induced free radical release is important in the pathogenesis of several diseases, including atherosclerosis and sepsis. Heme oxygenase (HO) breaks down heme into carbon monoxide, iron, and biliverdin.
Mirrin J. Dorresteijn, Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Suzanne Heemskerk, Hennie M.J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A.D.T.G. Wagener, Peter Pickkers   +10 more
doaj   +1 more source

Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding [PDF]

Journal of Molecular Biology, 2018
Biliverdin reductase B (BLVRB) is a newly identified cellular redox regulator that catalyzes the NADPH-dependent reduction of multiple substrates. Through mass spectrometry analysis, we identified high levels of BLVRB in mature red blood cells, highlighting the importance of BLVRB in redox regulation.
Natasia, Paukovich, Mengjun, Xue, James R, Elder, Jasmina S, Redzic, Ashley, Blue, Hamish, Pike, Brian G, Miller, Todd M, Pitts, David D, Pollock, Kirk, Hansen, Angelo, D'Alessandro, Elan Zohar, Eisenmesser   +11 more
openaire   +2 more sources

Murine Biocompatibility Evaluation of an Albumin‐Derived Complex and Nanoparticle Delivery System for Ocular Applications

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi, Nagaraj Kerur, Matthew P. Ohr, Andre F. Palmer, Katelyn E. Swindle‐Reilly   +4 more
wiley   +1 more source

A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid, Jieliang Huang, Shaofang Kong, Chengze Lai, Zhuoxin Tan, Yiming Shao, Lianxian Guo   +6 more
wiley   +1 more source

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron–sulphur cluster assembly pathways

The Journal of Physiology, Volume 604, Issue 5, Page 2229-2249, 1 March 2026.
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Veronica B. Botha, Heather C. Murray, Siddharth Acharya, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher   +5 more
wiley   +1 more source

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

Antioxidants, 2020
Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders.
Chiara Lanzillotta, Ilaria Zuliani, Chirag Vasavda, Solomon H. Snyder, Bindu D. Paul, Marzia Perluigi, Fabio Di Domenico, Eugenio Barone   +7 more
doaj   +1 more source

Safety evaluation of blue galdieria extract as a food additive

EFSA Journal, Volume 24, Issue 3, March 2026.
Abstract The EFSA Panel on Food Additive and Flavourings (FAF Panel) provides a scientific opinion on the safety of blue galdieria extract as a food additive. Blue galdieria extract is an enzymatically treated C‐phycocyanin extract derived from the lysed biomass of the microalgae Galdieria sulphuraria.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, José Manuel Barat Baviera, Gisela Degen, David Gott, Lieve Herman, Jean‐Charles Leblanc, Peter Moldeus, Ine Waalkens‐Berendsen, Detlef Wölfle, Civitella Consuelo, Ana Maria Rincon, Alexandra Tard, Alessandra Tosato, Panagiota Zakidou, Laura Ruggeri   +30 more
wiley   +1 more source

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

Neurobiology of Disease, 2019
Hyper-active GSK-3β favors Tau phosphorylation during the progression of Alzheimer's disease (AD). Akt is one of the main kinases inhibiting GSK-3β and its activation occurs in response to neurotoxic stimuli including, i.e., oxidative stress.
Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone   +9 more
doaj   +1 more source