Results 41 to 50 of about 107,951 (150)
, 2013 Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer's disease, but the ...
PERLUIGI, Marzia +5 more
core +1 more source
Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Role of Heme Oxygenase in Gastrointestinal Epithelial Cells
Antioxidants, 2022 The gastrointestinal tract is a unique organ containing both vascular and luminal routes lined by epithelial cells forming the mucosa, which play an important role in the entry of nutrients and act as a selective barrier, excluding potentially harmful ...
Reiko Akagi
doaj +1 more source
Protocol for the assay of biliverdin by the recombinant protein HUG
, 2022 Biliverdin is a secondary metabolite of heme catabolism. It is formed by the reaction catalyzed by heme oxygenase, which converts the heme group contained in proteins, such as hemoglobin, myoglobin, cytochromes, and catalase, to biliverdin, iron (II ...
Paola Sist +3 more
core +1 more source
Food Frontiers, Volume 7, Issue 5, September 2026.Ochratoxin A exposure induced MASLD and obesity in a sex‐specific manner. Disruption in adipocytokine signaling pathway and vitamin D metabolism led to lipid remodeling and obesity in females. However, activation of PPAR signaling pathway and ferroptosis contributed to lipid remodeling and obesity in males.
Meng Li +8 more
wiley +1 more source
Evolutionary insights into bilin biosynthesis: Functional characterization of pre‐PcyA enzymes
Protein Science, Volume 35, Issue 9, September 2026.Abstract Biosynthesis of the linear tetrapyrrole phycocyanobilin (PCB) by the ferredoxin‐dependent bilin reductase (FDBR) PcyA is essential for light‐harvesting and regulatory processes in diverse photosynthetic organisms, yet its evolutionary origins are not fully understood. PcyA evolved from pre‐PcyA proteins found in diverse bacteria.
Federica Frascogna +3 more
wiley +1 more source
Carbon Monoxide: A Context-Dependent Regulator of the Stress Axis
BiomoleculesCarbon monoxide (CO) is a gasotransmitter generated by heme oxygenase (HO) isoforms during heme catabolism. The inducible HO-1 produces CO under conditions of redox imbalance, such as oxidative stress and inflammation.
Cesare Mancuso, Rosaria Santangelo
doaj +1 more source
Bilirubin, Renal Hemodynamics and Blood Pressure
Frontiers in Pharmacology, 2012 Bilirubin is generated from the breakdown of heme by heme oxygenase and the reduction of biliverdin by the enzyme biliverdin reductase. Several large population studies have reported a significant inverse correlation between plasma bilirubin levels and ...
David E. Stec +2 more
doaj +1 more source
Antioxidants, 2022 The beneficial effects of Korean red ginseng extract (KRGE) on the central nervous system (CNS) have been reported. Among the CNS cells, astrocytes possess robust antioxidative properties and regenerative potential.
Sunhong Moon +6 more
doaj +1 more source
The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley +1 more source