Results 61 to 70 of about 183 (125)

INHIBITION OF BILIVERDIN REDUCTASE DIMINISHED THE PROTECTIVE ACTIVITY OF BILIRUBIN AND BILIVERDIN AGAINST OXIDATIVE STRESS-INDUCED INJURY IN HUMAN VASCULAR ENDOTHELIUM

Acta Chimica Slovenica
Endothelial dysfunction, a key factor in cardiovascular diseases, is further aggravated by oxidative stress. Biliverdin (BV) and bilirubin (BR) are potent antioxidants that protect endothelial cells, with biliverdin reductase (BVR) converting BV to BR ...
Kuldeepak Sharma, Irena Zajc, Alen Albreht, Lovro Ziberna   +3 more
doaj   +1 more source

Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq

BMC Genomics, 2019
Background The diversity of avian eggshell colour plays important biological roles in ensuring successful reproduction. Eggshell colour is also an important trait in poultry, but the mechanisms underlying it are poorly understood in ducks.
Ding-Ping Bai, Xin-Yu Lin, Yan Wu, Shi-Ye Zhou, Zhong-bin Huang, Yi-Fan Huang, Ang Li, Xiao-Hong Huang   +7 more
doaj   +1 more source

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real‐World Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Ahenk Zeynep Sayin, Lars Kuepfer
wiley   +1 more source

Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout

Nature Communications
Performance of near-infrared probes and optogenetic tools derived from bacterial phytochromes is limited by availability of their biliverdin chromophore.
Ludmila A. Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V. Verkhusha   +12 more
doaj   +1 more source

Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.

Journal of Biological Chemistry, 1994
This report describes for the first time the identification of four forms of biliverdin reductase including two biliverdin-IX beta reductases and two biliverdin-IX alpha reductases, designated isozymes I and II and isozymes III and IV, respectively, in human liver cytosolic fractions. The four forms of biliverdin reductase were purified to homogeneity.
T, Yamaguchi, Y, Komoda, H, Nakajima
openaire   +2 more sources

Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells

Biotechnology Progress, Volume 42, Issue 1, January/February 2026.
Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan, Griffin J. Beyer, Naomi Goosby, Lilly Ortiz, Andre F. Palmer   +4 more
wiley   +1 more source

From companionship to science: the importance of dogs in advancing translational research on Alzheimer's disease – a scoping review

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Rodent and primate models have advanced Alzheimer's disease (AD) research but are limited by anatomical differences, engineered pathologies, and aging trajectories that diverge from human neurodegeneration. Conversely, companion dogs naturally develop canine cognitive dysfunction (CCD), a progressive condition with behavioral and ...
Heloísa Máximo Ribeiro, Vanessa Alexandre‐Silva, Klysse Assumpção Barbosa, Rogério Martins Amorim, Didier Quevedo Cagnini, Marcia Regina Cominetti   +5 more
wiley   +1 more source

Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a progressive, life‐threatening disease characterized by vascular remodeling, endothelial dysfunction, and chronic inflammation. Despite existing targeted therapies, long‐term outcomes remain poor, underscoring the need for more effective treatment.
Yalei Wang, Jiacheng Wu, Qian Ma, Hao Chen, Erha Lama, Yulu Yang, Jianwu Huang, Changhu Liu, Xiaofei Ni, Zhihua Qiu, Zihua Zhou, Sami Deniz   +11 more
wiley   +1 more source

Urobilin Derived from Bilirubin Bioconversion Binds Albumin and May Interfere with Bilirubin Interacting with Albumin: Implications for Disease Pathology

Biomedicines
Background/Objectives: Bilirubin is a hydrophobic molecule that binds the carrier protein albumin for transport through systemic circulation. Bilirubin is cleared from the body through the liver and excreted into the intestines, where the microbiota ...
Kevin I. Williams, Priyanka Suryadevara, Chang-Guo Zhan, Terry D. Hinds, Zachary A. Kipp   +4 more
doaj   +1 more source

Sodium Nitrate Combined With Dental Pulp Stem Cells Alleviates Atherosclerosis Through Inhibiting Oxidative Stress

Stem Cells International, Volume 2026, Issue 1, 2026.
Atherosclerosis (AS), a leading cause of cardiovascular disease (CVD), is closely associated with excessive oxidative stress. Dietary nitrate has emerged as a promising intervention for cardiovascular protection through the nitrate–nitrite–nitric oxide (NO) pathway. Meanwhile, dental pulp stem cell (DPSC) possess potent antioxidant properties. However,
Zhuang Mao, Han Duan, Zhichao He, Lin Lv, Haichao Yu, Hu Cao, Jingyuan Shao, Xuesong Zhang, Shunying Hu, Hua Wang, Harleen Khatra   +10 more
wiley   +1 more source