Results 81 to 90 of about 107,951 (150)

Murine Biocompatibility Evaluation of an Albumin‐Derived Complex and Nanoparticle Delivery System for Ocular Applications

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi, Nagaraj Kerur, Matthew P. Ohr, Andre F. Palmer, Katelyn E. Swindle‐Reilly   +4 more
wiley   +1 more source

Specificity of biliverdin reductase [PDF]

Biochemical Journal, 1970
E, Colleran, P O, Carra
openaire   +2 more sources

Molecular Modeling to Provide Insight into the Substrate Binding and Catalytic Mechanism of Human Biliverdin-IXα Reductase

, 2016
Human biliverdin-IXα reductase (hBVR-A) catalyzes the conversion of biliverdin-IXα to bilirubin-IXα in the last step of heme degradation and is a key enzyme in regulating a wide range of cellular responses.
Gang Fu (728533), Haining Liu (1328499), Robert J. Doerksen (1328514)   +2 more
core   +1 more source

Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway

Cancer Management and Research, 2020
Haiyan Mao,1,2 Yuan Xu,1 Zhengrong Zhang,1 Guozhuang Sun,3 Zhu Wang,1 Dawei Qiao,2 Xudong Yin,1 Siping Liu,4 Ping Bo2 1Oncology Department, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu Province 225000, People ...
Mao H, Xu Y, Zhang Z, Sun G, Wang Z, Qiao D, Yin X, Liu S, Bo P   +8 more
doaj  

Anti-Inflammatory and Cell Signalling Effects of Biliverdin and Biliverdin Reductase

, 2014
Despite advances in medical care and research, sepsis still poses a great threat to the health of society and remains a major cause of mortality and morbidity throughout the world. The progression of sepsis is driven by inflammatory processes.
Bisht, Kavita
core   +1 more source

Mechanistic studies on human liver Biliverdin-IX beta reductase

, 2006
THESIS 7976The reaction mechanism of human biliverdin-IX? reductase (BVR-B) has been investigated using a number of approaches. The preference for NADPH over NADH has been examined using site-directed mutagenesis. The crystal structure of BVR-B, reported
Browne, Seamus
core  

Bilirubin: an endogenous molecule with antiviral activity in vitro.

Frontiers in Pharmacology, 2012
Bilirubin-IX-alpha (BR) is the final product of heme metabolism through the heme oxygenase/biliverdin reductase (HO/BVR) system. Previous papers reported on the microbicidal effects of the HO by-products biliverdin-IX-alpha, carbon monoxide and iron ...
Rosaria eSantangelo, Cesare eMancuso, Simona eMarchetti, Enrico eDi Stasio, Giovambattista ePani, Giovanni eFadda   +5 more
doaj   +1 more source

Biliverdin Amides Reveal Roles for Propionate Side Chains in Bilin Reductase Recognition and in Holophytochrome Assembly and Photoconversion

, 2016
Linear tetrapyrroles (bilins) perform important antioxidant and light-harvesting functions in cells from bacteria to humans. To explore the role of the propionate moieties in bilin metabolism, we report the semisynthesis of mono- and diamides of ...
Shelley S. Martin (1299066), Lixia Shang (2282110), J. Clark Lagarias (1299060), Nathan C. Rockwell (1299063)   +3 more
core   +1 more source

Mechanistic and functional studies on biliverdin IXa reductase from the cyanobacterium synechocystis sp.PCC6803

, 2009
THESIS 8724The enzymes of heme metabolism and phycobilin biosynthesis in the cyanobacterium Synechocystis sp. PCC6803, along with their reducing partners, ferredoxin and ferredoxin reductase were produced through recombinant DNA techniques and displayed ...
Hayes, Jerrard Michael
core  

Properties and kinetics of biliverdin reductase [PDF]

Biochemical Journal, 1971
P, O Carra, E, Colleran
openaire   +2 more sources