Results 81 to 90 of about 183 (125)

Biliverdin reductase-A is a key modulator in insulin signaling and metabolism

Trends in Endocrinology & Metabolism
Biliverdin reductase-A (BVRA) is a pleiotropic enzyme traditionally known for its antioxidant role in the heme degradation pathway. Recent findings have redefined BVRA as a master regulator of insulin signaling, acting as a kinase, scaffold, and redox-sensitive integrator of metabolic cues.
Tramutola, Antonella, Di Domenico, Fabio, Perluigi, Marzia, Barone, Eugenio   +3 more
openaire   +3 more sources

Biliverdin reductase B as a new target in breast cancer

Breast Cancer Research
Abstract Background Enhanced metabolic and mitochondrial activity inherent in actively proliferating cancer cells is associated with intracellular redox imbalance that impacts cellular viability. To restore redox homeostasis cancer cells evolve to activate redox protective mechanisms.
Marchenko, Natalia, Nesbitt, Natasha M., Alexandrova, Evguenia, Reisz, Julie A., D’Alessandro, Angelo, Suh, Joonhyuk, Uryasev, Stan, Pennacchia, Lisa, Bahou, Wadie F.   +8 more
openaire   +4 more sources

Biliverdin reductase A is a major determinant of protective NRF2 signaling

Proceedings of the National Academy of Sciences
Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity ...
Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S. Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E. Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M. Snowman, Michael C. Ostrowski, Eugenio Barone, Lakshminarayan M. Iyer, L. Aravind, Sudarshana M. Sharma, Andrew A. Pieper, Bobby Thomas, Solomon H. Snyder, Bindu D. Paul   +21 more
openaire   +3 more sources

Biliverdin Reductase A [PDF]

, 2020
openaire   +1 more source

Characterization of Cyanobacterial Biliverdin Reductase [PDF]

Journal of Biological Chemistry, 1997
Wendy M. Schluchter, Alexander N. Glazer
openaire   +1 more source

Studies on the Specificity of the Tetrapyrrole Substrate for Human Biliverdin-IXα Reductase and Biliverdin-IXβ Reductase [PDF]

Journal of Biological Chemistry, 2000
Orla Cunningham, Aisling Dunne, Portia Sabido, David Lightner, Timothy J. Mantle   +4 more
openaire   +1 more source

Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes

Journal of Diabetes Investigation
Aims/Introduction To investigate the predictive value of the biliverdin reductase‐A (BVR‐A) and the homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to ...
Li Shen, Xiaole Wei, Nan Wang, Haorui Lv, Jing Huang, Xiaoyan Zhou, Aifang Cheng, Changjiang Ying   +7 more
doaj   +1 more source

Structure of Biliverdin Reductase

Seibutsu Butsuri, 2000
A. Kikuchi, S-Y. Park, H. Miyatake, Y. Shiro, D. Sun, M. Sato, T. Yoshida   +6 more
openaire   +2 more sources

Biliverdin Reductase of Guinea Pig Liver

Journal of Biological Chemistry, 1965
J W, Singleton, L, Laster
openaire   +2 more sources

Kinetic studies on biliverdin-IXalpha reductase

, 2019
The species distribution of biliverdin-IXa reductase (BVR-A) has been reinvestigated. It appears increasingly likely that birds and amphibia have the potential to express an active biliverdin-IXa reductase. The full length cDNAs encoding human, Danio rerio, murine, and Xenopus BVR-A were successfully amplified and cloned into various expression vectors.
openaire   +1 more source