Results 11 to 20 of about 183 (125)
Frontiers in Cellular Neuroscience, 2020 Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár +10 more
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Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua. [PDF]
PLoS ONE, 2014 The bilin-binding proteins (BBP) from lepidopteran insects are members of the lipocalin family of proteins and play a special role in pigmentation through the binding of biliverdin IXγ.
Ana B G Veiga +5 more
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Scalable production of biliverdin IXα by
BMC Biotechnology, 2012 Background Biliverdin IXα is produced when heme undergoes reductive ring cleavage at the α-methene bridge catalyzed by heme oxygenase. It is subsequently reduced by biliverdin reductase to bilirubin IXα which is a potent endogenous antioxidant ...
Chen Dong +4 more
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Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
Frontiers in Molecular Biosciences, 2021 The biliverdin reductase B (BLVRB) class of enzymes catalyze the NADPH-dependent reduction of multiple flavin substrates and are emerging as critical players in cellular redox regulation.
Jasmina S. Redzic +5 more
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Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins
Cell Structure and Function, 2020 Tissue absorbance, light scattering, and autofluorescence are significantly lower in the near-infrared (NIR) range than in the visible range. Because of these advantages, NIR fluorescent proteins (FPs) are in high demand for in vivo imaging. Nevertheless, application of NIR FPs such as iRFP is still limited due to their dimness in mammalian cells.
Sumiyama, Kenta +5 more
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Biliverdin reductase and bilirubin in hepatic disease [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2018 The buildup of fat in the liver (hepatic steatosis) is the first step in a series of incidents that may drive hepatic disease. Obesity is the leading cause of nonalcoholic fatty liver disease (NAFLD), in which hepatic steatosis progresses to liver disease.
Lauren Weaver +3 more
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Physiological antioxidative network of the bilirubin system in aging and age-related diseases
Frontiers in Pharmacology, 2012 Oxidative stress is detrimental to life processes and is particularly responsible for aging and age-related diseases. Thus, most organisms are well equipped with a spectrum of biological defense mechanisms against oxidative stress.
Sung Young eKim, Sang Chul ePark
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Biliverdin reductase: A major physiologic cytoprotectant [PDF]
Proceedings of the National Academy of Sciences, 2002 Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Bilirubin is a potent antioxidant that we show can protect cells from a 10,000-fold excess of H 2 O
David E, Baranano +3 more
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The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases
Frontiers in Cell and Developmental Biology, 2022 Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), free iron and biliverdin, which could then be converted to bilirubin by biliverdin reductase.
Qing Yang, Wenqian Wang
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Haematologica, 2011 Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano +10 more
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