Results 1 to 10 of about 131 (109)
Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway
Molecules, 2023 Bilobalide exhibits numerous beneficial bioactivities, including neuroprotective, anti-inflammatory, and antioxidant activity. Our previous study demonstrated that bilobalide inhibits adipogenesis and promotes lipolysis.
Fuliang Cao, Su Bu, Faycal Aissa brahim
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Bilobalide modulates serotonin-controlled behaviors in the nematode
BMC Neuroscience, 2009 Background Dysfunctions in the serotonergic system have been implicated in several neurological disorders such as depression. Elderly individuals who have been diagnosed with clinical depression show elevated cases of neurodegenerative diseases. This has
Luo Yuan, Brown Marishka K
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Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway
Molecules, 2019 Bilobalide, the only sesquiterpene compound from Ginkgo biloba leaf, exhibits various beneficial pharmaceutical activities, such as antioxidant, anti-inflammation, and protective effects for the central nervous system.
Fuliang Cao, Su Bu
exaly +3 more sources
Lactone-to-Lactam Editing Alters the Pharmacology of Bilobalide
JACS AuPrecise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. Here, we report an unprecedented lactone-to-lactam transformation on bilobalide, thus improving its stability and paving the way for biological exploration of previously ...
Xiaoding Jiang +20 more
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Frontiers in Veterinary Science, 2022 Osteoarthritis (OA) is a common chronic musculoskeletal disease reported in veterinary clinics that severely reduces the quality of life of animals. The natural product, bilobalide, has positive effects on chondroprotection but its exact mechanism of ...
Tianwen Ma +13 more
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Frontiers in Pharmacology, 2022 Although osteoarthritis (OA) significantly affects the quality of life of the elderly, there is still no effective treatment strategy. The standardized Ginkgo biloba L.
Tianwen Ma +21 more
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Concise asymmetric synthesis of (−)-bilobalide [PDF]
Nature, 2019 The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood1-4. Antagonism of γ-aminobutyric acid A receptors (GABAARs) by bilobalide has been linked to the rescue of cognitive deficits in mouse models of Down syndrome5.
Baker, Meghan A. +3 more
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Translational Psychiatry, 2021 The pathogenesis of Alzheimer’s disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in single cell type may not be sufficient to treat AD and therapies with protective ...
Jun Xiang +8 more
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Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling
Antioxidants, 2023 The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents of the extract of Ginkgo biloba, are investigated in silico (level of theory: (SMD)-M06-2X/6-311+G(d,p)//M06-2X/6-31G(d)).
Davide Zeppilli +5 more
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Molecules, 2021 The present study compared the effects of natural senescence and methyl jasmonate (JA-Me) treatment on the levels of terpene trilactones (TTLs; ginkgolides and bilobalide), phenolic acids, and flavonoids in the primary organs of Ginkgo biloba leaves ...
Marcin Horbowicz +5 more
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