Exploring the protective potential of bilobalide against amyloid beta peptide 1‐42‐induced toxicity in BE(2)‐M17 cells: insights via cell viability and cellular energetics [PDF]
Alzheimer's &Dementia, Volume 20, Issue S6, December 2024.Abstract Background Reliable treatment approaches for addressing early cognitive impairment and Alzheimer’s disease (AD) are currently lacking. Given the multifactorial nature of AD, therapeutic strategies need to focus on disease‐specific biochemical pathways.
Manas Chakraborty +2 more
wiley +3 more sources
Bilobalide attenuates steroid-induced osteonecrosis of the femoral head by upregulating the ERK/HIF-1α signaling pathway and promoting angiogenesis-osteogenesis coupling [PDF]
Scientific ReportsSteroid-induced osteonecrosis of the femoral head (SONFH) is a severe bone disease associated with long-term glucocorticoid use, characterized by impaired bone metabolism and vascular insufficiency.
Qi Chen +5 more
doaj +3 more sources
Synthetic Studies on Bilobalide [PDF]
Synlett, 2020 We disclose our synthetic studies on bilobalide, which features a Diels–Alder reaction of a cyclic anhydride to form two contiguous quaternary carbon centers, desymmetrization of a symmetric diol, and construction of a cyclic acetal under acidic conditions with inversion of configuration at an allylic position.
Akihiro Shiogai +2 more
openaire +3 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Ischemic stroke is a leading cause of long-term disability. To date, there is no effective treatment for stroke. Previous studies have shown that Ginkgo biloba extract has protective effects against neurodegenerative disorders.
Yongqiu Zheng +7 more
doaj +3 more sources
11-Step Asymmetric Synthesis of (–)-Bilobalide [PDF]
, 2019 The Ginkgo biloba metabolite bilobalide (BB) is widely ingested but poorly understood. However, its antagonism of gamma -aminobutyric acid A receptors (GABA A R) has been tied to rescue of cognitive deficits in mouse models of ...
Meghan Baker +3 more
core +5 more sources
Journal of Pharmaceutical Analysis, 2021 There is an urgent need to elucidate the pathogenesis of myocardial ischemia (MI) and potential drug treatments. Here, the anti-MI mechanism and material basis of Ginkgo biloba L.
Zhe Wang +5 more
doaj +2 more sources
Bilobalide increases SKCa current via 5-HT2BR-PLC–PKC pathway, causing hyperpolarization and enhanced EET production in human coronary artery endothelial cells [PDF]
BMC Complementary Medicine and TherapiesBackground Ginkgo biloba extract and its active component bilobalide induce endothelium-dependent vasodilation in coronary and other vascular beds. This effect is associated with increased Ca2+-activated K+ channel activity in endothelial cells. We aimed
Katesirin Ruamyod +4 more
doaj +2 more sources
A Catuama e o bilobalide na regeneração nervosa periférica de ratos submetidos à secção do nervo isquiático [PDF]
Ciência Rural, 2014 A Catuama® é a associação de quatro extratos hidroalcoolicos obtidos de plantas brasileiras (Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides e Zingiber officinale) com conhecida ação neuroprotetora, anti-inflamatória, antioxidante e ...
Rodrigo Norberto Pereira +5 more
doaj +2 more sources
Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)-Linked Neuroinflammation. [PDF]
Adv Sci (Weinh)Natural products offer privileged three‐dimensional chemotypes for drug discovery, yet scaffold lability and limited analogue space often impede mechanism‐guided optimization.
Sillapachaiyaporn C +20 more
europepmc +2 more sources
Nutraceuticals, 2023 The phytochemical profiles of extracts from closed, semi-opened and opened leaf buds and the summer leaves of Ginkgo biloba were studied. The extraction and purification of bilobalide and ginkgolides, using andrographolide as an internal standard, were ...
Dominique Laurain-Mattar +5 more
doaj +2 more sources