Results 31 to 40 of about 1,516 (196)

Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-휅B pathways in rats

BMC Musculoskeletal Disorders, 2020
Background Clinically, skeletal muscle ischemia/reperfusion injury is a life-threatening syndrome that is often caused by skeletal muscle damage and is characterized by oxidative stress and inflammatory responses.
Ying Li, Jiliang Jiang, Liangcheng Tong, Tingting Gao, Lei Bai, Qing Xue, Jianxin Xing, Qin Wang, Haoran Lyu, Min Cai, Zhongyang Sun   +10 more
doaj   +1 more source

Time-Dependent Induction of Hepatic Cytochrome P450 Enzyme Activity and mRNA Expression by Bilobalide in Rats

Journal of Pharmacological Sciences, 2009
A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats.
Yuko Taki, Yuko Yamazaki, Fumio Shimura, Shizuo Yamada, Keizo Umegaki   +4 more
doaj   +1 more source

Herbal medicines from ginkgo leaf extract in the treatment of mild dementia [PDF]

Arhiv za farmaciju, 2020
According to current EU monograph of the Committee on Herbal Medicinal Products of European Medicines Agency (EMA/HMPC) for ginkgo leaf, Ginkgonis folium (Ginkgo biloba, Ginkgoaceae), herbal medicines prepared from refined and quantified dry extract of ...
Petrović Silvana, Ušjak Ljuboš
doaj   +1 more source

Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (−)-Bilobalide [PDF]

, 2020
Here we interrogate the structurally dense (1.64 mcbits/Å3) GABAA receptor antagonist bilobalide, intermediates en route to its synthesis, and related mechanistic questions. 13C isotope labeling identifies an unexpected bromine migration en route to an α-
Houk, Kendall N, Demoret, Robert M, Roberto, Marisa, Shenvi, Ryan A, Ohtawa, Masaki, Lam, Ching Ching, Khom, Sophia, Baker, Meghan A, Chen, Shuming, Forli, Stefano   +9 more
core   +1 more source

Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice

Journal of Pharmacy & Pharmaceutical Sciences, 2010
. Purpose. Bilobalide is an active constituent of Ginkgo biloba and has shown neuroprotective effects in mice with cerebral ischemia. In the present study, we investigated brain permeability of bilobalide (i) in healthy mice and (ii) in mice before or ...
Dorothee Lang, Christian Ude, Mario Wurglics, Manfred Schubert-Zsilavecz, Jochen Klein   +4 more
doaj   +1 more source

Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo [PDF]

, 2011
Neuroprotective properties of bilobalide, a specific constituent of Ginkgo extracts, were tested in a mouse model of stroke. After 24 h of middle cerebral artery occlusion (MCAO), bilobalide reduced infarct areas in the core region (striatum) by 40–50 ...
Alexander Mdzinarishvili, Dorothee Lang, Tina Maria Schwarzkopf, Mdzinarishvili, Alexander, Hartmann, Joachim, Cornelia Kiewert, Klein, Jochen, Jochen Klein, Joachim Hartmann, Kiewert, Cornelia, Sumbria, Rachita K., Lang, Dorothee, Schwarzkopf, Tina Maria, Rachita Sumbria   +13 more
core   +1 more source

Enhancing amplification of late‐outgrowth endothelial cells by bilobalide [PDF]

Journal of Cellular and Molecular Medicine, 2018
AbstractTransfusion of autologous late‐outgrowth endothelial cells (OECs) is a promising treatment for restenosis after revascularization. Preparing cells by in vitro amplification is a key step to implement the therapy. This study aimed to demonstrate that bilobalide, a terpenoid, enhances the OEC amplification.
Shuqin Liu, Xiaoye Hou, Lina Chen, Hao Hu, Qiang Sun, Feng Zhao, Chuanhao Liu   +6 more
openaire   +2 more sources

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

Revista Brasileira de Plantas Medicinais, 2014
Electrocardiographic effects produced by Ginkgo biloba extract (EGb) and by ginkgolides A (GA) and B (GB), and bilobalide (BB) were investigated in guinea pig heart mounted in Langendorff apparatus (Tyrode, 34 ± 0.1 ºC, 95% O2, 5% CO2 ...
A.C.O. Santos, J.A.S. Souza, E.A. Conde-Garcia, A.A. Souza, J.E.R. Menezes-Filho, E.D. Oliveira, C.M.L Vasconcelos   +6 more
doaj   +1 more source

Gingko biloba-inspired lactone prevents osteoarthritis by activating the AMPK-SIRT1 signaling pathway

Arthritis Research & Therapy, 2022
Background Uncoupled extracellular matrix (ECM) causes cartilage degeneration and osteoarthritis (OA) by suppressing the synthesis and activating the degradation of ECM components.
Zhijian Zhao, Yang Liu, Yingjie Lu, Mingzhuang Hou, Xu Shen, Huilin Yang, Qin Shi, Yijian Zhang, Fan He, Xuesong Zhu   +9 more
doaj   +1 more source

Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures [PDF]

, 2006
The effect of precursor feeding on the production of bilobalide and ginkgolides was studied with suspension cell cultures of Ginkgo biloba. The precursors greatly influenced the productivity of bilobalide and ginkgolides.
Kim, Y.-D., Karigar, C.S., Min, J.-Y., Ha, Y.-L., Kang, S.-M., Jung, H.-N., Kim, S.-W., Choi, M.-S., Park, D.-J.   +8 more
core   +1 more source