Results 1 to 10 of about 8,384,443 (422)

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Cell, 2020
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutralizing antibodies.
Tyler N Starr, Allison J Greaney, Sarah K Hilton   +2 more
exaly   +3 more sources

A large-scale binding and functional map of human RNA-binding proteins

Nature, 2020
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the ...
Ines Rabano, Balaji Sundararaman, Bing Zhou   +2 more
exaly   +2 more sources

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Nature, 2020
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors 1 – 4 , followed by fusion of the virus and cell membranes to release the virus genome into the cell.
Steven J Gamblin, Antoni G Wrobel, Donald J Benton   +2 more
exaly   +2 more sources

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Nature, 2020
Jun Lan, Jiwan Ge, Jinfang Yu
exaly   +2 more sources

Expansive Concretes for Shotcrete in Tunnel Construction [PDF]

MATEC Web of Conferences, 2021
This paper presents the results of investigation of properties of fine-grained concrete on expansive cement for fiber-reinforced shotcretes used for metro tunneling. Basic factors affecting material expansion after mixing with water are described.
Kharchenko Igor, Panchenko Alexander, Kharchenko Aleksey   +2 more
doaj   +1 more source

To bind or not to bind [PDF]

Nature, 2013
Finding a way to control how particles bind to cells could open up opportunities for biomedical research. The discovery of a method for directing the orientation of particle–cell interactions is therefore a cause for excitement.
O'Connor, AJ, Caruso, F
openaire   +2 more sources

Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies

bioRxiv, 2021
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum antibodies are impacted by all mutations to the spike’s ...
Allison J. Greaney, Andrea N. Loes, K. H. Crawford, Tyler N. Starr, Keara D. Malone, H. Chu, J. Bloom   +6 more
semanticscholar   +1 more source

Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums

Scientific Reports, 2021
Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian   +5 more
doaj   +1 more source

Automatic Normalization of Temporal Expressions

Journal of Computer Applications in Archaeology, 2023
Dates, periods and timespans are described in archaeological datasets using a number of different textual patterns for which myriad variations exist, rendering direct automated comparison difficult.
Ceri Binding, Douglas Tudhope
doaj   +1 more source

Cooperative Binding [PDF]

PLoS Computational Biology, 2013
Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration.
Stefan, Melanie I., Le Novère, Nicolas   +1 more
openaire   +7 more sources