Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Using the Intrinsic Fluorescence of DNA to Characterize Aptamer Binding
The reliable, readily accessible and label-free measurement of aptamer binding remains a challenge in the field. Recent reports have shown large changes in the intrinsic fluorescence of DNA upon the formation of G-quadruplex and i-motif structures.
Chang Lu +3 more
doaj +1 more source
An interview with Paul Binding [PDF]
Paul Binding is a British writer who has worked in many fields: he is a literary critic, novelist, reviewer and renowned expert in Scandinavian literature.
Paul Binding, Turner, Nick
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Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies [PDF]
Advances in understanding how GroEL binds to non-native proteins are reported. Conformational flexibility in the GroEL apical domain, which could account for the variety of substrates that GroEL binds, is illustrated by comparison of several independent ...
Adams +62 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Étude du comportement mécanique d’une reliure de la fin du XVe siècle – Le Missel de Cambrai
The article concerns the restoration of an incunabula printed in 1495 in Paris. Our goal was to adapt our interventions taking into account the various constituent materials of the medieval book: leather, wood, sewing and fittings.
Lara Meersseman
doaj +1 more source
Al-Wa‘d as Muhallil of Multi Contract (Ambiguity of Applying Al-Wa'd in Modern Transaction) [PDF]
Wa'd (the unilateral promise) is an alternative for separate multi contract in one transaction and ribâ that are prohibited with Islamic law. The application of this promise faces difficulty because of difference of principle between unilateral promise ...
Maksum, M. (Muhammad)
core +2 more sources
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF
Neisseria meningitidis, Haemophilus influenzae, and Moraxella catarrhalis are pathogenic bacteria adapted to reside on human respiratory mucosal epithelia.
Matthew L. Brewer +5 more
doaj +1 more source
Information Extraction Techniques for the Purposes of Semantic Indexing of Archaeological Resources [PDF]
The paper describes the use of Information Extraction (IE), a Natural Language Processing (NLP) technique to assist ‘rich’ semantic indexing of diverse archaeological text resources.
Binding, C, Tudhope, D, Vlachidis, A
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