Results 51 to 60 of about 3,573,689 (297)

The interpretative options of anaphoric complex demonstratives

open access: yesGlossa, 2022
In this paper, we present experimental evidence from a ‘yes’/‘no’ judgement task and two acceptability rating studies (Experiments 1a-c) for the claim made in Hinterwimmer (2019) that sentences with two anaphorically interpreted complex demonstratives ...
Stefan Hinterwimmer, Umesh Patil
doaj   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integration of exteroceptive and interoceptive information within the hippocampus: a computational study

open access: yesFrontiers in Systems Neuroscience, 2015
Many episodic memory studies have critically implicated the hippocampus in the rapid binding of sensory information from the perception of the external environment, reported by exteroception.
Randa eKassab   +5 more
doaj   +1 more source

Remarks on Rule H

open access: yesGlossa, 2021
Fox (2000) argues that a single principle, Rule H, can account for (i) Strong Crossover, (ii) the ban on using co-binding to sneak around Condition B, and (iii) the Dahl paradigm. The focus of this paper is Fox’s analysis of the Dahl paradigm.
Alex Drummond
doaj   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF

open access: yesJournal of Oral Microbiology, 2019
Neisseria meningitidis, Haemophilus influenzae, and Moraxella catarrhalis are pathogenic bacteria adapted to reside on human respiratory mucosal epithelia.
Matthew L. Brewer   +5 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice

open access: yesFrontiers in Molecular Neuroscience, 2023
Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in regulating neuronal excitability. We previously found that GABA directly binds to and activates channels containing KCNQ3, challenging the traditional understanding of ...
Kiki J. Chen   +8 more
doaj   +1 more source

DNA-binding residues and binding mode prediction with binding-mechanism concerned models [PDF]

open access: yesBMC Genomics, 2009
Protein-DNA interactions are essential for fundamental biological activities including DNA transcription, replication, packaging, repair and rearrangement. Proteins interacting with DNA can be classified into two categories of binding mechanisms - sequence-specific and non-specific binding. Protein-DNA specific binding provides a mechanism to recognize
Oyang Yen-Jen   +4 more
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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