Results 51 to 60 of about 8,384,443 (422)
Predicting biomolecular binding kinetics: A review [PDF]
arXiv, 2022 Biomolecular binding kinetics including the association (kon) and dissociation (koff) rates are critical parameters for therapeutic design of small-molecule drugs, peptides and antibodies. Notably, drug molecule residence time or dissociation rate has been shown to correlate with their efficacies better than binding affinities. A wide range of modeling
arxiv
Time-Based Binding as a Solution to and a Limitation for Flexible Cognition
Frontiers in Psychology, 2022 Why can’t we keep as many items as we want in working memory? It has long been debated whether this resource limitation is a bug (a downside of our fallible biological system) or instead a feature (an optimal response to a computational problem).
Mehdi Senoussi +2 more
doaj +1 more source
Leptin Binding and Binding Capacity in Serum [PDF]
Clinical Chemistry, 2000 Abstract Background: Leptin, a hormone produced primarily by adipose tissue, is known to be present in serum as both monomeric (free) and higher molecular mass (bound) forms, but little is known about the nature of the bound forms or physiological variation in binding capacity.
openaire +3 more sources
Extended tight‐binding quantum chemistry methods
, 2020 This review covers a family of atomistic, mostly quantum chemistry (QC) based semiempirical methods for the fast and reasonably accurate description of large molecules in gas and condensed phase.
Christoph Bannwarth +7 more
semanticscholar +1 more source
Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
Nature Communications, 2020 Study of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike
Jinsung Yang +9 more
semanticscholar +1 more source
miRWalk: An online resource for prediction of microRNA binding sites
PLoS ONE, 2018 miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow.
C. Sticht +3 more
semanticscholar +1 more source
Competitive ligand binding kinetics to linear polymers [PDF]
Physical Review E 107, 024401 (2023)Different types of ligands compete in binding to polymers with different consequences for the physical and chemical properties of the resulting complex. Here, we derive a general kinetic model for the competitive binding kinetics of different types of ligands to a linear polymer, using the McGhee and von Hippel detailed binding site counting procedure.
arxiv +1 more source
Switch-like surface binding of competing multivalent particles [PDF]
, 2016 Multivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface.
arxiv +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Riesz Bases of Root Vectors of Indefinite Sturm-Liouville problems with eigenparameter dependent boundary conditions, I [PDF]
, 2007 We consider a regular indefinite Sturm-Liouville problem with two self-adjoint boundary conditions, one being affinely dependent on the eigenparameter.
Binding, Paul, Ćurgus, Branko
core +5 more sources