Results 1 to 10 of about 8,730,538 (402)

Cheminformatic analysis of protein surfaces provides binding site insights and informs identification strategies. [PDF]

Future Med Chem
Milisavljević A, Pražnikar J, Bren U, Jukič M.   +3 more
europepmc   +2 more sources

IGA MULTIPLE MYELOMA ASSESMENT WITH HEVYLITE ASSAY

Hematology, Transfusion and Cell Therapy, 2023
Introduction: A key element on Multiple Myeloma (MM) evaluation is the quantification of monoclonal proteins. Current techniques include Serum Protein Electrophoresis (SPE), Immunofixation (IFE) and Free Light Chain Assay (FLC, Freelite).
G Virginia, C Silvina, F Delgado, EM Soares   +3 more
doaj   +1 more source

The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Diagnostics, 2021
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients.
Rafael Ríos-Tamayo, Noemí Puig, Macarena Algarín, José Luís García de Veas Silva, Nuno Barbosa, Cristina Encinas, José Ángel Hernández, Rafael Alonso, María Luisa Campos, Teresa Rodríguez, Alberto Leivas, María José Olivares, María José Sánchez, Bruno Paiva, Juan José Lahuerta, Joaquín Martínez-López   +15 more
doaj   +1 more source

Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023
Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins.
David R. Barnidge, Angela Dispenzieri, Dragan Jevremovic, David L. Murray   +3 more
doaj   +1 more source

Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor

Frontiers in Physiology, 2023
Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor.
Balázs Nemes, Szabolcs László, Szabolcs László, Balázs Zoltán Zsidó, Csaba Hetényi, Adam Feher, Ferenc Papp, Zoltan Varga, Éva Szőke, Zoltán Sándor, Erika Pintér   +10 more
doaj   +1 more source

Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

Pharmaceuticals, 2020
It is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies. Microtubules are predominantly composed of the protein tubulin, which contains a number of different binding ...
Eavan C. McLoughlin, Niamh M. O’Boyle
semanticscholar   +1 more source

In silico prediction of the transcription factor-enhancer interaction as a first stage of axonal growth regulation

Сеченовский вестник, 2023
The development of neurodegenerative diseases is associated with proper neuronal circuit formation, axonal guidance. The DCC receptor (deleted in colorectal cancer / colorectal cancer suppressor) and SHH (sonic hedgehog protein) are among the key ...
D. D. Kotelnikov, I. A. Sinyakin, E. A. Borodin, T. A. Batalova   +3 more
doaj   +1 more source

Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Aerobic glycolysis is a breast cancer hallmark that has become a novel target for anticancer therapy. GLUT1, HK2, PKM2, and LDHA are oncogenic proteins in the pathway.
Honesty N. Pinanti, Yuyun I. Christina, Muhaimin Rifa’i, Nashi Widodo, Muhammad S. Djati   +4 more
doaj   +1 more source

The Mechanism of Dynamic Interaction between Doxorubicin and Calf Thymus DNA at the Single-Molecule Level Based on Confocal Raman Spectroscopy

Micromachines, 2022
It is of great fundamental significance and practical application to understand the binding sites and dynamic process of the interaction between doxorubicin (DOX) and DNA molecules.
Ruihong Zhang, Jie Zhu, Dan Sun, Jie Li, Lina Yao, Shuangshuang Meng, Yan Li, Yang Dang, Kaige Wang   +8 more
doaj   +1 more source

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression. [PDF]

Cell Rep
Shah K, Anastasakou E, Sejour L, Wang Y, Wert-Lamas L, Rauchet C, Studer S, Goller S, Distel RJ, Marasco W, Perera L, Vlachos IS, Novina CD.   +12 more
europepmc   +2 more sources