Results 1 to 10 of about 1,513,732 (317)
IGA MULTIPLE MYELOMA ASSESMENT WITH HEVYLITE ASSAY
Hematology, Transfusion and Cell Therapy, 2023 Introduction: A key element on Multiple Myeloma (MM) evaluation is the quantification of monoclonal proteins. Current techniques include Serum Protein Electrophoresis (SPE), Immunofixation (IFE) and Free Light Chain Assay (FLC, Freelite).
G Virginia +3 more
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Diagnostics, 2021 Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients.
Rafael Ríos-Tamayo +15 more
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Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023 Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins.
David R. Barnidge +3 more
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Galactoside-Binding Site in LacY [PDF]
Biochemistry, 2014 Although an X-ray crystal structure of lactose permease (LacY) has been presented with bound galactopyranoside, neither the sugar nor the residues ligating the sugar can be identified with precision at ~3.5 Å. Therefore, additional evidence is important for identifying side chains likely to be involved in binding.
Jiang, Xiaoxu +4 more
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Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Aerobic glycolysis is a breast cancer hallmark that has become a novel target for anticancer therapy. GLUT1, HK2, PKM2, and LDHA are oncogenic proteins in the pathway.
Honesty N. Pinanti +4 more
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Computing the protein binding sites [PDF]
BMC Bioinformatics, 2011 Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions.
Lusheng Wang, Fei Guo, Fei Guo
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Сеченовский вестник, 2023 The development of neurodegenerative diseases is associated with proper neuronal circuit formation, axonal guidance. The DCC receptor (deleted in colorectal cancer / colorectal cancer suppressor) and SHH (sonic hedgehog protein) are among the key ...
D. D. Kotelnikov +3 more
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P53 Binding Sites in Transposons [PDF]
Frontiers in Genetics, 2012 Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Zemojtel, T., Vingron, M.
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Being a binding site: Characterizing residue composition of binding sites on proteins [PDF]
Bioinformation, 2007 The Protein Data Bank contains the description of more than 45,000 three-dimensional protein and nucleic-acid structures today. Started to exist as the computer-readable depository of crystallographic data complementing printed articles, the proper interpretation of the content of the individual files in the PDB still frequently needs the detailed ...
Ivan, G, Szabadka, Z, Grolmusz, V
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Plants, 2021 Miltiradiene synthase (MS) genes, TwTPS27a and TwTPS27b, are the key diterpene synthase genes in the biosynthesis of triptolide, which is an important medicinally active diterpenoid in Tripterygium wilfordii.
Yanbo Huo +5 more
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