Results 1 to 10 of about 2,877,073 (306)

IGA MULTIPLE MYELOMA ASSESMENT WITH HEVYLITE ASSAY

Hematology, Transfusion and Cell Therapy, 2023
Introduction: A key element on Multiple Myeloma (MM) evaluation is the quantification of monoclonal proteins. Current techniques include Serum Protein Electrophoresis (SPE), Immunofixation (IFE) and Free Light Chain Assay (FLC, Freelite).
G Virginia, C Silvina, F Delgado, EM Soares   +3 more
doaj   +1 more source

The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Diagnostics, 2021
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients.
Rafael Ríos-Tamayo, Noemí Puig, Macarena Algarín, José Luís García de Veas Silva, Nuno Barbosa, Cristina Encinas, José Ángel Hernández, Rafael Alonso, María Luisa Campos, Teresa Rodríguez, Alberto Leivas, María José Olivares, María José Sánchez, Bruno Paiva, Juan José Lahuerta, Joaquín Martínez-López   +15 more
doaj   +1 more source

Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor

Frontiers in Physiology, 2023
Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor.
Balázs Nemes, Szabolcs László, Szabolcs László, Balázs Zoltán Zsidó, Csaba Hetényi, Adam Feher, Ferenc Papp, Zoltan Varga, Éva Szőke, Zoltán Sándor, Erika Pintér   +10 more
doaj   +1 more source

In silico prediction of the transcription factor-enhancer interaction as a first stage of axonal growth regulation

Сеченовский вестник, 2023
The development of neurodegenerative diseases is associated with proper neuronal circuit formation, axonal guidance. The DCC receptor (deleted in colorectal cancer / colorectal cancer suppressor) and SHH (sonic hedgehog protein) are among the key ...
D. D. Kotelnikov, I. A. Sinyakin, E. A. Borodin, T. A. Batalova   +3 more
doaj   +1 more source

Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Aerobic glycolysis is a breast cancer hallmark that has become a novel target for anticancer therapy. GLUT1, HK2, PKM2, and LDHA are oncogenic proteins in the pathway.
Honesty N. Pinanti, Yuyun I. Christina, Muhaimin Rifa’i, Nashi Widodo, Muhammad S. Djati   +4 more
doaj   +1 more source

The Mechanism of Dynamic Interaction between Doxorubicin and Calf Thymus DNA at the Single-Molecule Level Based on Confocal Raman Spectroscopy

Micromachines, 2022
It is of great fundamental significance and practical application to understand the binding sites and dynamic process of the interaction between doxorubicin (DOX) and DNA molecules.
Ruihong Zhang, Jie Zhu, Dan Sun, Jie Li, Lina Yao, Shuangshuang Meng, Yan Li, Yang Dang, Kaige Wang   +8 more
doaj   +1 more source

Comprehensive Survey of Consensus Docking for High-Throughput Virtual Screening

Molecules, 2022
The rapid advances of 3D techniques for the structural determination of proteins and the development of numerous computational methods and strategies have led to identifying highly active compounds in computer drug design.
Clara Blanes-Mira, Pilar Fernández-Aguado, Jorge de Andrés-López, Asia Fernández-Carvajal, Antonio Ferrer-Montiel, Gregorio Fernández-Ballester   +5 more
doaj   +1 more source

Isolation and Functional Characterization of the Promoters of Miltiradiene Synthase Genes, TwTPS27a and TwTPS27b, and Interaction Analysis with the Transcription Factor TwTGA1 from Tripterygium wilfordii

Plants, 2021
Miltiradiene synthase (MS) genes, TwTPS27a and TwTPS27b, are the key diterpene synthase genes in the biosynthesis of triptolide, which is an important medicinally active diterpenoid in Tripterygium wilfordii.
Yanbo Huo, Bin Zhang, Ling Chen, Jing Zhang, Xing Zhang, Chuanshu Zhu   +5 more
doaj   +1 more source

Prediction of DNA-Binding Protein–Drug-Binding Sites Using Residue Interaction Networks and Sequence Feature

Frontiers in Bioengineering and Biotechnology, 2022
Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang, Wei Wang, Yu Zhang, Dong Liu, Dong Liu, HongJun Zhang, XianFang Wang, Yun Zhou   +7 more
doaj   +1 more source

Influence of N–1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor [PDF]

Journal of the Serbian Chemical Society, 2006
Serotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology.
MARIO V. ZLATOVIC, GORAN M. ROGLIC, DEANA B. ANDRIC, SLADJANA V. KOSTIC-RAJACIC, VLADIMIR V. SUKALOVIC   +4 more
doaj   +3 more sources