Results 1 to 10 of about 8,138,457 (428)

Identifying short motifs by means of extreme value analysis [PDF]

Europhysics Letters 84 18001 (2008), 2008
The problem of detecting a binding site -- a substring of DNA where transcription factors attach -- on a long DNA sequence requires the recognition of a small pattern in a large background. For short binding sites, the matching probability can display large fluctuations from one putative binding site to another.
, , , B. Tirozzi, Bianchi D. Tirozzi B., Bourdeau V., Coles S. G., Cordero F., D. Bianchi, Embrechts P., Wood J.   +10 more
arxiv   +3 more sources

The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Diagnostics, 2021
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients.
Rafael Ríos-Tamayo, Noemí Puig, Macarena Algarín, José Luís García de Veas Silva, Nuno Barbosa, Cristina Encinas, José Ángel Hernández, Rafael Alonso, María Luisa Campos, Teresa Rodríguez, Alberto Leivas, María José Olivares, María José Sánchez, Bruno Paiva, Juan José Lahuerta, Joaquín Martínez-López   +15 more
doaj   +1 more source

Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

Pharmaceuticals, 2020
It is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies. Microtubules are predominantly composed of the protein tubulin, which contains a number of different binding ...
Eavan C. McLoughlin, Niamh M. O’Boyle
semanticscholar   +1 more source

Computing the protein binding sites [PDF]

BMC Bioinformatics, 2011
Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions.
Lusheng Wang, Fei Guo, Fei Guo
openaire   +4 more sources

P53 Binding Sites in Transposons [PDF]

Frontiers in Genetics, 2012
Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Zemojtel, T., Vingron, M.
openaire   +5 more sources

Being a binding site: Characterizing residue composition of binding sites on proteins [PDF]

Bioinformation, 2007
The Protein Data Bank contains the description of more than 45,000 three-dimensional protein and nucleic-acid structures today. Started to exist as the computer-readable depository of crystallographic data complementing printed articles, the proper interpretation of the content of the individual files in the PDB still frequently needs the detailed ...
Ivan, G, Szabadka, Z, Grolmusz, V
openaire   +3 more sources

Structural Analysis and Stochastic Modelling Suggest a Mechanism for Calmodulin Trapping by CaMKII [PDF]

, 2012
Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Le Novère, Nicolas, Marshall, David P., Stefan, Melanie I.   +2 more
core   +6 more sources

Prediction of DNA-Binding Protein–Drug-Binding Sites Using Residue Interaction Networks and Sequence Feature

Frontiers in Bioengineering and Biotechnology, 2022
Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang, Wei Wang, Yu Zhang, Dong Liu, Dong Liu, HongJun Zhang, XianFang Wang, Yun Zhou   +7 more
doaj   +1 more source

Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor

Frontiers in Physiology, 2023
Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor.
Balázs Nemes, Szabolcs László, Szabolcs László, Balázs Zoltán Zsidó, Csaba Hetényi, Adam Feher, Ferenc Papp, Zoltan Varga, Éva Szőke, Zoltán Sándor, Erika Pintér   +10 more
doaj   +1 more source

Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Aerobic glycolysis is a breast cancer hallmark that has become a novel target for anticancer therapy. GLUT1, HK2, PKM2, and LDHA are oncogenic proteins in the pathway.
Honesty N. Pinanti, Yuyun I. Christina, Muhaimin Rifa’i, Nashi Widodo, Muhammad S. Djati   +4 more
doaj   +1 more source