Results 131 to 140 of about 8,774,932 (333)

Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key

PLoS ONE, 2013
Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) – a drug’s ability to bind to several targets. There is a long standing debate on
V. J. Haupt, Simone Daminelli, M. Schroeder   +2 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Escherichia coli phage ΦPNJ-9 adheres to mucus via a variant Hoc protein

Journal of Virology
Phages, as antagonists of bacteria, hold significant promise for combating drug-resistant bacterial infections. Their host specificity allows phages to target pathogenic bacteria without disrupting the gut microbiota, offering distinct advantages in the ...
Kailai Fu, Jiaqi Cui, Yao Li, Yuhan Zhang, Yang Wang, Jiaoling Wu, Xinru Chen, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang   +10 more
doaj   +1 more source

High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors [PDF]

, 1998
Roman Urfer, Pantelis Tsoulfas, Lori O'Connell, Jo-Anne Hongo, Wei Zhao, Leonard G. Presta   +5 more
openalex   +1 more source

Robust transcriptome-wide discovery of RNA binding protein binding sites with enhanced CLIP (eCLIP)

Nature Methods, 2016
As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA molecules, binding site identification by UV crosslinking and immunoprecipitation (CLIP) of ribonucleoprotein complexes is critical to understanding
Eric L. Van Nostrand, G. Pratt, Alexander A. Shishkin, C. Gelboin-Burkhart, Mark Y. Fang, B. Sundararaman, S. Blue, Thai B. Nguyen, Christine Surka, Keri Elkins, Rebecca Stanton, F. Rigo, M. Guttman, Gene W. Yeo   +13 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Binding and Activating of Analgesic Crotalphine with Human TRPA1

Membranes
TRPA1 (Transient Receptor Potential Ankyrin 1), a cation channel predominantly expressed in sensory neurons, plays a critical role in detecting noxious stimuli and mediating pain signal transmission.
Mingmin Kang, Yanming Zhang, Xiufang Ding, Jianfu Xu, Xiaoyun Pang   +4 more
doaj   +1 more source

High affinity ryanodine binding sites in rat liver endoplasmic reticulum [PDF]

, 1990
Varda Shoshan‐Barmatz
openalex   +1 more source

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Nature, 2020
R. Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lian-ao Wu, G. Gao, Xue Hu, Yanan Zhang, Z. Tong, Weijing Huang, William J. Liu, Guizhen Wu, Bo Zhang, Lan Wang, J. Qi, H. Feng, Fu-Sheng Wang, Qihui Wang, G. Gao, Zhiming Yuan, Jinghua Yan   +25 more
semanticscholar   +1 more source

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR*

Journal of Biological Chemistry, 2001
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and FcRn ...
R. Shields, Angela K. Namenuk, K. Hong, Y. Meng, J. Rae, J. Briggs, Dong Xie, Jadine Lai, Andrew D. Stadlen, Betty Li, J. Fox, L. Presta   +11 more
semanticscholar   +1 more source