Results 151 to 160 of about 1,513,732 (317)

Targeting the RAGE-RIPK1 binding site attenuates diabetes-associated cognitive deficits. [PDF]

J Neuroinflammation
Gao L, Wu S, Hu B, Zhang Q, Wu Y, Li H, Qian Y, Huang C, Wen X, Li H, Cheng A, Song Y, Ying C, Zhou X.   +13 more
europepmc   +1 more source

Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis.

, 1978
Örjan Wränge, Jan-Ακε Gustafsson
openalex   +1 more source

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

Revealing the location and dynamics of a concealed binding site in the dopamine transporter. [PDF]

Nat Commun
Zhu R, Sandtner W, Stockner T, Heilinger A, Holy M, Kudlacek O, Wildling L, Saha K, Fröhlich AS, Bindl M, Tziortzouda P, Haider A, Gobl J, Suh SH, Khan JA, Bicher J, Kastner N, Ebner A, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.   +22 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

PrankWeb 4: a modular web server for protein-ligand binding site prediction and downstream analysis. [PDF]

Nucleic Acids Res
Polák L, Škoda P, Riedlová K, Krivák R, Novotný M, Hoksza D.   +5 more
europepmc   +1 more source

The nuclear envelope. The major site of insulin binding in rat liver nuclei.

, 1978
Riccardo Vigneri, Ira D. Goldfine, K. Y. Wong, George J. Smith, V. Pezzino   +4 more
openalex   +1 more source

Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. [PDF]

, 1977
J H Oppenheimer, Ermelinda Santos Silva, Harold L. Schwartz, Martin I. Surks   +3 more
openalex   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies. [PDF]

Nat Commun
Hassan B, Chandravanshi M, Ng MY, Negi H, Wilson BAP, Walters KJ.   +5 more
europepmc   +1 more source