Results 11 to 20 of about 1,513,732 (317)
Frontiers in Bioengineering and Biotechnology, 2022 Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang +7 more
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Comprehensive Survey of Consensus Docking for High-Throughput Virtual Screening
Molecules, 2022 The rapid advances of 3D techniques for the structural determination of proteins and the development of numerous computational methods and strategies have led to identifying highly active compounds in computer drug design.
Clara Blanes-Mira +5 more
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miR-496 inhibits proliferation via LYN and AKT pathway in gastric cancer
Open Medicine, 2021 MicroRNAs (miRNAs) operate as tumor suppressor or carcinogen to regulate cell proliferation, metastasis, invasion, differentiation, apoptosis, and metabolic process.
Su Rui, Zhao Enhong, Zhang Jun
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Micromachines, 2022 It is of great fundamental significance and practical application to understand the binding sites and dynamic process of the interaction between doxorubicin (DOX) and DNA molecules.
Ruihong Zhang +8 more
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Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations
BMC Immunology, 2019 Background We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after ...
Antony R. Parker +5 more
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Practical Laboratory Medicine, 2016 Objectives: Anti-pneumococcal capsular polysaccharide (PCP) IgM, IgG and IgA ELISAs have been developed to aid assessment of the adaptive immune system. The relationship between the concentrations of PCP IgM, IgG, and IgA was investigated.
Antony R. Parker +2 more
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Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
Frontiers in Physiology, 2023 Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor.
Balázs Nemes +10 more
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Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function
Biomolecules, 2022 GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4).
Kate M. Crowther +2 more
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Frontiers in Immunology, 2019 Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant ...
Felicity Kendrick +4 more
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Influence of N–1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor [PDF]
Journal of the Serbian Chemical Society, 2006 Serotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology.
MARIO V. ZLATOVIC +4 more
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