Results 191 to 200 of about 1,513,732 (317)

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin. [PDF]

EMBO J
Zhou X, Chen H, Peng S, Si Y, Wang G, Yang L, Zhou Q, Lu M, Xie Q, He X, Wu M, Xiao X, Luo X, Feng X, Wang W, Luo S, Li Y, Qin J, Chen M, Zhang Q, Hu W, Liang S, Hou T, Liu Z.   +23 more
europepmc   +1 more source

Localization of the binding site for cell attachment in the alpha1(I) chain of collagen

, 1978
Hynda K. Kleinman, Ermona B. McGoodwin, George R. Martin, Robert J. Klebe, Peter P. Fietzek, David E. Woolley   +5 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Colchicine Binding Site Tubulin Inhibitors Impair Vincristine-Resistant Neuroblastoma Cell Function. [PDF]

Molecules
Reed CN, Garrison KB, Thammathong J, Cinatl J, Michaelis M, Banerjee S, Weissmiller AM.   +6 more
europepmc   +1 more source

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

, 1977
Ira D. Goldfine, George J. Smith, K. Y. Wong, A. L. Jones   +3 more
openalex   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Moldrug algorithm for an automated ligand binding site exploration by 3D aware molecular enumerations. [PDF]

J Cheminform
Martínez León A, Ries B, Hub JS, Magarkar A.   +3 more
europepmc   +1 more source

Effects of Phagocytosis and Colchicine on the Distribution of Lectin-Binding Sites on Cell Surfaces

, 1974
Janet M. Oliver, T. E. Ukena, R D Berlin
openalex   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site. [PDF]

iScience
Wang LL, Keiser P, Yang D, Seravalli J, Patten JJ, Eaton B, Anderson D, Liu Y, Holbrook MR, Smith AB, Davey RA, Xiang SH.   +11 more
europepmc   +1 more source