Results 201 to 210 of about 2,892,311 (358)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

MVRBind: multi-view learning for RNA-small molecule binding site prediction. [PDF]

Brief Bioinform
Chen S, Huang Z, Wang Y, Li Y, Tan YS, Deng L, Wu M.   +6 more
europepmc   +1 more source

Location of Ribosomal Protein Binding Sites on 16S Ribosomal RNA

, 1972
Robert A. Zimmermann, Akira Muto, Peter Fellner, Chantal Ehresmann, Christiane Branlant   +4 more
openalex   +1 more source

Dansylation of human serum albumin in the study of the primary binding sites of bilirubin and l-tryptophan [PDF]

, 1979
Christian Jacobsen, Jan Jacobsen
openalex   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Correction to "Benchmarking Zinc-Binding Site Predictors: A Comparative Analysis of Structure-Based Approaches". [PDF]

J Chem Inf Model
Ciofalo C, Laveglia V, Andreini C, Rosato A.   +3 more
europepmc   +1 more source

Crystallographic determination of the heme orientation and location of the cyanide binding site in yeast cytochrome c peroxidase.

, 1978
T.L. Poulos, Stephan T. Freer, Richard A. Alden, N.-H. Xuong, S.L. Edwards, R. Hamlin, J. Kraut   +6 more
openalex   +1 more source

Identical VL Region Sequences of Two Antibodies from Two Outbred Rabbits Exhibiting Complete Idiotypic Cross-Reactivity and Probably the Same Antigen-Binding Site Fine Structure [PDF]

, 1978
Daniel Ch. Brandt, Jean‐Claude Jaton
openalex   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Cryo-EM reveals an extrahelical allosteric binding site at the M₅ mAChR. [PDF]

Nat Commun
Burger WAC, Mobbs JI, Rana B, Wang J, Joshi K, Gentry PR, Yeasmin M, Venugopal H, Bender AM, Lindsley CW, Miao Y, Christopoulos A, Valant C, Thal DM.   +13 more
europepmc   +1 more source