Results 211 to 220 of about 8,730,538 (402)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Bacterial transcription factor binding site inference as the basis for the study of plant-microbial interactions

, 2020
Ye. A. Nikolaichik
openalex   +1 more source

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1 [PDF]

, 2017
Ariel Lewis-Ballester, Khoa Pham, Dipanwita Batabyal, Shay Karkashon, J.B. Bonanno, T.L. Poulos, Syun‐Ru Yeh   +6 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Residues of the ribose binding site are required for human ribokinase activity. [PDF]

J Struct Biol X
Ferreira JC, Nedyalkova L, Villanueva AJ, Fadl S, Cinviz ZN, Adem KA, Sensoy O, Rabeh WM.   +7 more
europepmc   +1 more source

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.

Proceedings of the National Academy of Sciences of the United States of America, 2004
B. Lynch, N. Lambeng, K. Nocka, Patricia Kensel-Hammes, S. Bajjalieh, A. Matagne, B. Fuks   +6 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Investigation of a cryptic ligand binding site on Plasmodium falciparum Hsp90. [PDF]

Bioorg Med Chem
Mansfield CR, Taggart EL, Chirgwin ME, Derbyshire ER.   +3 more
europepmc   +1 more source

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1 [PDF]

, 1995
Christine Skerka, Eva L. Decker, Peter F. Zipfel   +2 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source