Results 51 to 60 of about 8,774,932 (333)

How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?

Frontiers in Chemistry, 2018
Knowledge of the bioactive conformations of small molecules or the ability to predict them with theoretical methods is of key importance to the design of bioactive compounds such as drugs, agrochemicals, and cosmetics.
Nils-Ole Friedrich, Méliné Simsir, Méliné Simsir, Johannes Kirchmair   +3 more
doaj   +1 more source

Insight on a Competitive Nucleophilic Addition Reaction of Nε-(Carboxymethyl) Lysine or Different Amino Acids with 4-Methylbenzoquinone

Foods, 2022
ο-benzoquinone is a common intermediate which is mostly formed by the oxidation of phenolics or polyphenols containing catechol structure. ο-benzoquinone has an outstanding nucleophilic ability, while advanced glycation end products (AGEs) are ...
Zhenhui Zhang, Lin Li, Yuting Li, Yi Wu, Xia Zhang, Haiping Qi, Bing Li   +6 more
doaj   +1 more source

Effect of Tetraphenylborate on Physicochemical Properties of Bovine Serum Albumin

Molecules, 2021
The binding interactions of bovine serum albumin (BSA) with tetraphenylborate ions ([B(Ph)4]−) have been investigated by a set of experimental methods (isothermal titration calorimetry, steady-state fluorescence spectroscopy, differential scanning ...
Ola Grabowska, Małgorzata M. Kogut, Krzysztof Żamojć, Sergey A. Samsonov, Joanna Makowska, Aleksandra Tesmar, Katarzyna Chmur, Dariusz Wyrzykowski, Lech Chmurzyński   +8 more
doaj   +1 more source

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. [PDF]

, 2017
In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces.
Gorraitz, Edurne, Hirayama, Bruce A, Loo, Donald DF, Paz, Aviv, Wright, Ernest M   +4 more
core   +2 more sources

Characterization of α-actin isoforms in white and red skeletal muscle types of Leporinus macrocephalus (Characiformes, Anostomidae)

Anais da Academia Brasileira de Ciências, 2015
RESUMO Dois genes de α-actina do peixe Leporinus macrocephalus, referindo-se aos tecidos musculares branco e vermelho, foram isolados. Isoformas de actinas, que principalmente diferiram por uma substituição Ser/Ala155, podem ter uma significância ...
FERNANDA A. ALVES-COSTA, MAELI D.P. SILVA, ADRIANE P. WASKO   +2 more
doaj   +1 more source

Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions

Frontiers in Immunology, 2020
Helminths develop strategies to escape host immune responses that facilitate their survival in the hostile host immune environment. Trichinella spiralis, a tissue-dwelling nematode, has developed a sophisticated strategy to escape complement attack.
Shuai Shao, Chunyue Hao, Bin Zhan, Qinghui Zhuang, Limei Zhao, Yi Chen, Jingjing Huang, Xinping Zhu   +7 more
doaj   +1 more source

AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility

PLoS Comput. Biol., 2015
Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging.
P. Ravindranath, Stefano Forli, D. Goodsell, A. Olson, M. Sanner   +4 more
semanticscholar   +1 more source

Accurate Sequence-Based Prediction of Deleterious nsSNPs with Multiple Sequence Profiles and Putative Binding Residues

Biomolecules, 2021
Non-synonymous single nucleotide polymorphisms (nsSNPs) may result in pathogenic changes that are associated with human diseases. Accurate prediction of these deleterious nsSNPs is in high demand.
Ruiyang Song, Baixin Cao, Zhenling Peng, Christopher J. Oldfield, Lukasz Kurgan, Ka-Chun Wong, Jianyi Yang   +6 more
doaj   +1 more source

binding site [PDF]

, 2014
Citation: 'binding site' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.B00649 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Structure and Metal Binding Properties of ZnuA, a Periplasmic Zinc Transporter from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2008
ZnuA is the periplasmic Zn2+-binding protein associated with the high-affinity ATP-binding cassette ZnuABC transporter from Escherichia coli. Although several structures of ZnuA and its homologs have been determined, details regarding metal ion ...
Bennett, Brian, Breece, Robert M., Crowder, Michael W., Easton, J. Allen, Kim, Lydia R., Rosenzweig, Amy C., Sugarbaker, Stacy A., Tierney, David L., Vorontsov, Ivan I., Yatsunyk, Liliya A.   +9 more
core   +2 more sources