Results 51 to 60 of about 125,906 (194)
Bimolecular binding rates for pairs of spherical molecules with small binding sites [PDF]
arXiv, 2020 Bimolecular binding rate constants are often used to describe the association of large molecules, such as proteins. In this paper, we analyze a model for such binding rates that includes the fact that pairs of molecules can bind only in certain orientations.
arxiv
Coarse-grained molecular simulations of allosteric cooperativity [PDF]
J. Chem. Phys. 144, 105101 (2016), 2015 Interactions between a protein and a ligand are often accompanied by a redistribution of the population of thermally accessible conformations. This dynamic response of the protein's functional energy landscape enables a protein to modulate binding affinities and control binding sensitivity to ligand concentration.
arxiv +1 more source
Autophagy Reports, 2022 TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with ...
Rossella De Cegli +7 more
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Intermolecular Adhesion in Conjugated Polymers [PDF]
, 2006 Conjugated polymers are observed to aggregate in solution. To account for this observation we propose a inter-chain binding mechanism based on the intermolecular tunneling of the delocalized $\pi$-electrons occurring at points where the polymers cross. This tunneling mechanism predicts specific bound structures of chain that depend on whether they are ...
arxiv +1 more source
Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive learning [PDF]
arXiv, 2023 Protein-DNA interaction is critical for life activities such as replication, transcription, and splicing. Identifying protein-DNA binding residues is essential for modeling their interaction and downstream studies. However, developing accurate and efficient computational methods for this task remains challenging.
arxiv
Biomolecules, 2019 Since the discovery of a novel liver hyaluronan (HA) clearance receptor in 1981 by Laurent, Fraser and coworkers, 22 different ligands cleared by the renamed receptor (the Hyaluronan Receptor for Endocytosis (HARE); Stabilin-2 (Stab2)) were discovered ...
Paul H. Weigel
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Channel-Facilitated Molecular Transport Across Membranes: Attraction, Repulsion and Asymmetry [PDF]
, 2006 Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect on translocation dynamics.
arxiv +1 more source
Practical Laboratory Medicine, 2016 Objectives: Anti-pneumococcal capsular polysaccharide (PCP) IgM, IgG and IgA ELISAs have been developed to aid assessment of the adaptive immune system. The relationship between the concentrations of PCP IgM, IgG, and IgA was investigated.
Antony R. Parker +2 more
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Identifying short motifs by means of extreme value analysis [PDF]
Europhysics Letters 84 18001 (2008), 2008 The problem of detecting a binding site -- a substring of DNA where transcription factors attach -- on a long DNA sequence requires the recognition of a small pattern in a large background. For short binding sites, the matching probability can display large fluctuations from one putative binding site to another.
arxiv +1 more source
Utilidad del ensayo de cadenas livianas libres en suero en el manejo de gammapatías monoclonales
Revista Médica del Uruguay, 2014 El ensayo de cadenas livianas libres en suero cuantifica los niveles de κ y λ libres. Existen tres indicaciones principales para la medición de cadenas livianas libres en el manejo de pacientes con mieloma múltiple y enfermedades relacionadas.
María Florencia Delgado
doaj