Results 51 to 60 of about 8,730,538 (402)
Molecular Plant-Microbe Interactions, 2021 Identification of transcription factor binding sites is one of the most important steps in understanding the function of transcription factors and regulatory networks in organisms. The assay for transposase accessible chromatin sequencing (ATAC-seq) is a
Xiaoyang Chen +5 more
doaj +1 more source
AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility
PLoS Comput. Biol., 2015 Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging.
P. Ravindranath +4 more
semanticscholar +1 more source
Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]
, 1997 Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A. +2 more
core +1 more source
RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA [PDF]
, 2016 Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation.
BOZZONI, Irene +6 more
core +1 more source
How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?
Frontiers in Chemistry, 2018 Knowledge of the bioactive conformations of small molecules or the ability to predict them with theoretical methods is of key importance to the design of bioactive compounds such as drugs, agrochemicals, and cosmetics.
Nils-Ole Friedrich +3 more
doaj +1 more source
Foods, 2022 ο-benzoquinone is a common intermediate which is mostly formed by the oxidation of phenolics or polyphenols containing catechol structure. ο-benzoquinone has an outstanding nucleophilic ability, while advanced glycation end products (AGEs) are ...
Zhenhui Zhang +6 more
doaj +1 more source
The Na+ Binding Site of Thrombin [PDF]
Journal of Biological Chemistry, 1995 Thrombin is an allosteric serine protease existing in two forms, slow and fast, targeted toward anticoagulant and procoagulant activities. The slow --> fast transition is induced by Na+ binding to a site contained within a cylindrical cavity formed by three antiparallel beta-strands of the B-chain (Met180-Tyr184a, Lys224-Tyr228, and Val213-Gly219 ...
E, Di Cera +6 more
openaire +2 more sources
Unraveling determinants of transcription factor binding outside the core binding site
Genome Research, 2015 Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of gene expression. Despite many advances in the characterization of sequence motifs recognized by TFs, our ability to quantitatively predict TF binding to ...
M. Levo +9 more
semanticscholar +1 more source
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Science, 2020 Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan +7 more
semanticscholar +1 more source
Structure and Metal Binding Properties of ZnuA, a Periplasmic Zinc Transporter from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]
, 2008 ZnuA is the periplasmic Zn2+-binding protein associated with the high-affinity ATP-binding cassette ZnuABC transporter from Escherichia coli. Although several structures of ZnuA and its homologs have been determined, details regarding metal ion ...
Bennett, Brian +9 more
core +2 more sources