Results 51 to 60 of about 125,906 (194)

Bimolecular binding rates for pairs of spherical molecules with small binding sites [PDF]

open access: yesarXiv, 2020
Bimolecular binding rate constants are often used to describe the association of large molecules, such as proteins. In this paper, we analyze a model for such binding rates that includes the fact that pairs of molecules can bind only in certain orientations.
arxiv  

Coarse-grained molecular simulations of allosteric cooperativity [PDF]

open access: yesJ. Chem. Phys. 144, 105101 (2016), 2015
Interactions between a protein and a ligand are often accompanied by a redistribution of the population of thermally accessible conformations. This dynamic response of the protein's functional energy landscape enables a protein to modulate binding affinities and control binding sensitivity to ligand concentration.
arxiv   +1 more source

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB

open access: yesAutophagy Reports, 2022
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with ...
Rossella De Cegli   +7 more
doaj   +1 more source

Intermolecular Adhesion in Conjugated Polymers [PDF]

open access: yes, 2006
Conjugated polymers are observed to aggregate in solution. To account for this observation we propose a inter-chain binding mechanism based on the intermolecular tunneling of the delocalized $\pi$-electrons occurring at points where the polymers cross. This tunneling mechanism predicts specific bound structures of chain that depend on whether they are ...
arxiv   +1 more source

Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive learning [PDF]

open access: yesarXiv, 2023
Protein-DNA interaction is critical for life activities such as replication, transcription, and splicing. Identifying protein-DNA binding residues is essential for modeling their interaction and downstream studies. However, developing accurate and efficient computational methods for this task remains challenging.
arxiv  

Discovery of the Liver Hyaluronan Receptor for Endocytosis (HARE) and Its Progressive Emergence as the Multi-Ligand Scavenger Receptor Stabilin-2

open access: yesBiomolecules, 2019
Since the discovery of a novel liver hyaluronan (HA) clearance receptor in 1981 by Laurent, Fraser and coworkers, 22 different ligands cleared by the renamed receptor (the Hyaluronan Receptor for Endocytosis (HARE); Stabilin-2 (Stab2)) were discovered ...
Paul H. Weigel
doaj   +1 more source

Channel-Facilitated Molecular Transport Across Membranes: Attraction, Repulsion and Asymmetry [PDF]

open access: yes, 2006
Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect on translocation dynamics.
arxiv   +1 more source

Concentration of anti-pneumococcal capsular polysaccharide IgM, IgG and IgA specific antibodies in adult blood donors

open access: yesPractical Laboratory Medicine, 2016
Objectives: Anti-pneumococcal capsular polysaccharide (PCP) IgM, IgG and IgA ELISAs have been developed to aid assessment of the adaptive immune system. The relationship between the concentrations of PCP IgM, IgG, and IgA was investigated.
Antony R. Parker   +2 more
doaj  

Identifying short motifs by means of extreme value analysis [PDF]

open access: yesEurophysics Letters 84 18001 (2008), 2008
The problem of detecting a binding site -- a substring of DNA where transcription factors attach -- on a long DNA sequence requires the recognition of a small pattern in a large background. For short binding sites, the matching probability can display large fluctuations from one putative binding site to another.
arxiv   +1 more source

Utilidad del ensayo de cadenas livianas libres en suero en el manejo de gammapatías monoclonales

open access: yesRevista Médica del Uruguay, 2014
El ensayo de cadenas livianas libres en suero cuantifica los niveles de κ y λ libres. Existen tres indicaciones principales para la medición de cadenas livianas libres en el manejo de pacientes con mieloma múltiple y enfermedades relacionadas.
María Florencia Delgado
doaj  

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