Results 31 to 40 of about 1,627,769 (335)

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

Nature Communications, 2023
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS) antibodies that exist in diverse individuals as public antibody clones. We rationally selected RBS antibodies resilient to mutations in emerging Omicron subvariants.
Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Shunsuke Kita, Yusuke Higuchi, Yuhei Kirita, Ryutaro Kotaki, Keisuke Tonouchi, Kohei Yumoto, Tateki Suzuki, Taiyou Someya, Hideo Fukuhara, Yudai Kuroda, Tsukasa Yamamoto, Taishi Onodera, Shuetsu Fukushi, Ken Maeda, Fukumi Nakamura-Uchiyama, Takao Hashiguchi, Atsushi Hoshino, Katsumi Maenaka, Yoshimasa Takahashi   +23 more
doaj   +1 more source

Structure-free antibody paratope similarity prediction for in silico epitope binning via protein language models

iScience, 2023
Summary: Antibodies are an important group of biological molecules that are used as therapeutics and diagnostic tools. Although millions of antibody sequences are available, identifying their structural and functional similarity and their antigen binding
Ahmadreza Ghanbarpour, Min Jiang, Denisa Foster, Qing Chai   +3 more
doaj   +1 more source

Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies

bioRxiv, 2021
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum antibodies are impacted by all mutations to the spike’s ...
Allison J. Greaney, Andrea N. Loes, K. H. Crawford, Tyler N. Starr, Keara D. Malone, H. Chu, J. Bloom   +6 more
semanticscholar   +1 more source

Structural Analysis of Anti-Hapten Antibodies to Identify Long-Range Structural Movements Induced by Hapten Binding

Frontiers in Molecular Biosciences, 2021
Antibodies are well known for their high specificity that has enabled them to be of significant use in both therapeutic and diagnostic applications. Antibodies can recognize different antigens, including proteins, carbohydrates, peptides, nucleic acids ...
Mohammed M. Al Qaraghuli, Mohammed M. Al Qaraghuli, Karina Kubiak-Ossowska, Karina Kubiak-Ossowska, Valerie A. Ferro, Paul A. Mulheran   +5 more
doaj   +1 more source

In Vivo Fluorescence Imaging of E-Selectin: Quantitative Detection of Endothelial Activation in Arthritis [PDF]

, 2010
Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage and bone.
Gompels, Luke, Gompels, Luke
core   +1 more source

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Nature Microbiology, 2021
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies–AZD8895 and AZD1061–which form
Jinhui Dong, Seth J. Zost, Allison J. Greaney, Tyler N. Starr, A. Dingens, E. Chen, Rita E. Chen, J. Case, Rachel E. Sutton, P. Gilchuk, Jessica Rodriguez, Erica Armstrong, Christopher Gainza, Rachel S. Nargi, E. Binshtein, Xuping Xie, Xianwen Zhang, P. Shi, James Logue, S. Weston, M. McGrath, M. Frieman, Tyler Brady, K. Tuffy, H. Bright, Y. Loo, P. McTamney, M. Esser, R. Carnahan, M. Diamond, J. Bloom, J. Crowe   +31 more
semanticscholar   +1 more source

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
core  

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]

, 2014
The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
core   +1 more source

Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

Virology Journal, 2012
Background Influenza virus undergoes rapid evolution by both antigenic shift and antigenic drift. Antibodies, particularly those binding near the receptor-binding site of hemagglutinin (HA) or the neuraminidase (NA) active site, are thought to be the ...
Stray Stephen J, Pittman Lindsey B
doaj   +1 more source

Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Biochemistry and Biophysics Reports, 2021
Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid ...
Filippo Benedetti, Florian Stracke, Gerhard Stadlmayr, Katharina Stadlbauer, Florian Rüker, Gordana Wozniak-Knopp   +5 more
doaj   +1 more source