Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. [PDF]
PLoS Pathogens, 2013 Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein.
Sowmya Sampath +9 more
doaj +1 more source
Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation [PDF]
, 2009 Single-domain antibody fragments (VHHs) have several beneficial properties as compared to conventional antibody fragments. However, their small size complicates their toxin- and virus-neutralizing capacity.
Fijten, H.P.D. +5 more
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GII.4 Human Norovirus: Surveying the Antigenic Landscape
Viruses, 2019 Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need
Michael L. Mallory +3 more
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Advanced Science, 2023 Antibody‐based therapies could be led astray when target receptors are expressed on nontarget sites, and the on‐target toxicity poses critical challenges to clinical applications. Here, a biomimetic indirect active targeting (INTACT) strategy is proposed
Zhongjie Tang +9 more
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Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]
, 1997 Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew +2 more
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Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.
PLoS ONE, 2016 We describe three recombinant engineered antibodies against three recombinant epitope tags, constructed with divalent binding arms to recognize divalent epitopes and so achieve high affinity and specificity.
Hongyu Zhao +3 more
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Scientific Reports, 2022 The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strategy for transporting protein-based drugs into
Andrés de la Rosa +8 more
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PLoS ONE, 2011 BackgroundCockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited.
Jill Glesner +7 more
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Identifying vaccine escape sites via statistical comparisons of short-term molecular dynamics
Biophysical Reports, 2022 The identification of viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution.
Madhusudan Rajendran +2 more
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Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain. [PDF]
, 2013 Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action.
Duerr, Harald +29 more
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