Results 31 to 40 of about 675,780 (316)

The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Scientific Reports, 2022
SARS-CoV-2 is the pathogen responsible for COVID-19 that has claimed over six million lives as of July 2022. The severity of COVID-19 motivates a need to understand how it could evolve to escape potential treatments and to find ways to strengthen ...
Jonathan E. Barnes, Peik K. Lund-Andersen, Jagdish Suresh Patel, F. Marty Ytreberg   +3 more
doaj   +1 more source

Outer Membrane Protein YadA of Enteropathogenic Yersiniae Mediates Specific Binding to Cellular but Not Plasma Fibronectin [PDF]

, 1993
The binding of bacteria or bacterial products to host proteins of tissue extracellular matrix may be a mechanism of tissue adherence. We investigated interactions of the plasmid-encoded outer membrane protein YadA, which confers pathogenic functions on ...
Emmerich, F., Burkhardt, H., Kirsch, T., Schulze-Koops, Hendrik, Swoboda, B., Bull, C., Goodman, S., Heesemann, Jürgen   +7 more
core   +1 more source

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

Nature Communications, 2023
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS) antibodies that exist in diverse individuals as public antibody clones. We rationally selected RBS antibodies resilient to mutations in emerging Omicron subvariants.
Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Shunsuke Kita, Yusuke Higuchi, Yuhei Kirita, Ryutaro Kotaki, Keisuke Tonouchi, Kohei Yumoto, Tateki Suzuki, Taiyou Someya, Hideo Fukuhara, Yudai Kuroda, Tsukasa Yamamoto, Taishi Onodera, Shuetsu Fukushi, Ken Maeda, Fukumi Nakamura-Uchiyama, Takao Hashiguchi, Atsushi Hoshino, Katsumi Maenaka, Yoshimasa Takahashi   +23 more
doaj   +1 more source

Peptide Linked Diacetylene Amphiphiles for Detection of Epitope Specific Antibodies

Chemosensors, 2022
Antibodies produced in response to adaptive immunity provide a receptor with multiple sites for binding to a distinct epitope of an antigen. Determining antibody levels to specific antigens has important clinical applications in assessing immune status ...
Natalie Tran, Priyanka Shiveshwarkar, Justyn Jaworski   +2 more
doaj   +1 more source

Structure and Dynamics of Stacking Interactions in an Antibody Binding Site [PDF]

Biochemistry, 2019
For years, antibodies (Abs) have been used as a paradigm for understanding how protein structure contributes to molecular recognition. However, with the ability to evolve Abs that recognize specific chromophores, they also have great potential as models for how protein dynamics contribute to molecular recognition.
Ramkrishna Adhikary, Jörg Zimmermann, Robyn L. Stanfield, Ian A. Wilson, Wayne Yu, Masayuki Oda, Floyd E. Romesberg   +6 more
openaire   +2 more sources

Expression of recombinant multi-coloured fluorescent antibodies in gor ^-/trxB^- E. coli cytoplasm [PDF]

, 2011
Background Antibody-fluorophore conjugates are invaluable reagents used in contemporary molecular cell biology for imaging, cell sorting and tracking intracellular events.
Durvasula, Ravi V., Burchell, Joy Marilyn; id_orcid, Kang, Angray S., Anatoliy Markiv, Burchell, J, Durvasula, R.V., Beatson, R., Beatson Richard, Beatson, Richard; id_orcid, Kang Angray S, Markiv, A., Markiv Anatoliy, Kang, A.S., Richard Beatson, Burchell, J., Durvasula Ravi V, Ravi V Durvasula, Burchell, Joy; id_orcid, Durvasula, RV, Markiv, Anatoliy, Burchell Joy, Markiv, A, Angray S Kang, Beatson, Richard, Joy Burchell, Kang, AS, Beatson, R   +26 more
core   +1 more source

Structure-free antibody paratope similarity prediction for in silico epitope binning via protein language models

iScience, 2023
Summary: Antibodies are an important group of biological molecules that are used as therapeutics and diagnostic tools. Although millions of antibody sequences are available, identifying their structural and functional similarity and their antigen binding
Ahmadreza Ghanbarpour, Min Jiang, Denisa Foster, Qing Chai   +3 more
doaj   +1 more source

Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

Virology Journal, 2012
Background Influenza virus undergoes rapid evolution by both antigenic shift and antigenic drift. Antibodies, particularly those binding near the receptor-binding site of hemagglutinin (HA) or the neuraminidase (NA) active site, are thought to be the ...
Stray Stephen J, Pittman Lindsey B
doaj   +1 more source

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source

Structural Analysis of Anti-Hapten Antibodies to Identify Long-Range Structural Movements Induced by Hapten Binding

Frontiers in Molecular Biosciences, 2021
Antibodies are well known for their high specificity that has enabled them to be of significant use in both therapeutic and diagnostic applications. Antibodies can recognize different antigens, including proteins, carbohydrates, peptides, nucleic acids ...
Mohammed M. Al Qaraghuli, Mohammed M. Al Qaraghuli, Karina Kubiak-Ossowska, Karina Kubiak-Ossowska, Valerie A. Ferro, Paul A. Mulheran   +5 more
doaj   +1 more source