Results 11 to 20 of about 675,780 (316)
Structural consensus among antibodies defines the antigen binding site. [PDF]
PLoS Computational Biology, 2012 The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site.
Vered Kunik, Bjoern Peters, Yanay Ofran
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Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses [PDF]
VirusesBackground: The H1N1 influenza A virus evades host immunity through continuous antigenic drift, posing a significant challenge to broad-spectrum neutralizing antibody therapies.
Weili Song +6 more
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Understanding antibody binding sites
, 2017 Antibodies are soluble proteins produced by the adaptive immune system to bind and counteract invading pathogens. The binding properties of a typical human antibody are determined by the structure of its variable domain, composed of two chains – heavy and light and by the conformation of six loops located on the surface of the variable domain, known as
Jaroslaw Nowak, Nowak, Jaroslaw
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A comparison of the binding sites of antibodies and single-domain antibodies
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity. Antibodies (Abs) and single-domain antibodies (sdAbs) differ in the structures of their binding sites: most significantly, single-domain antibodies lack a light chain and
Gemma L. Gordon +5 more
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mAbs, 2020 LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81
Karl J. M. Hanf +14 more
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Scientific Reports, 2021 Nervous necrosis virus (NNV) is a pathogenic fish-virus belonging to the genus Betanodavirus (Nodaviridae). Surface protrusions on NNV particles play a crucial role in both antigenicity and infectivity.
Hyun Jung Gye, Toyohiko Nishizawa
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Microbiology Spectrum, 2021 The rapid worldwide spread of SARS-CoV-2 has accelerated research and development for controlling the COVID-19 pandemic. A multi-coronavirus protein microarray was created containing full-length proteins, overlapping protein fragments of various lengths,
David Camerini +22 more
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Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin. [PDF]
PLoS ONE, 2011 Antigenic drift allowing escape from neutralizing antibodies is an important feature of transmission and survival of influenza viruses in host populations.
E Jane Homan, Robert D Bremel
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PLoS Pathogens, 2022 Exposure histories to SARS-CoV-2 variants and vaccinations will shape the specificity of antibody responses. To understand the specificity of Delta-elicited antibody immunity, we characterize the polyclonal antibody response elicited by primary or mRNA ...
Allison J Greaney +10 more
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Binding site of toxic protein from Arthrinium phaeospermum on plasmalemma of hybrid bamboo
浙江大学学报. 农业与生命科学版, 2012 To explore the binding site of toxic protein from Arthrinium phaeospermum on plasmalemma of hybrid bamboo and the binding activities of different hybrid bamboo varieties, based on the separation and purification of toxic protein by a low-pressure ...
LI Shu-jiang, ZHU Tian-hui
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