Results 41 to 50 of about 1,627,769 (335)

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Nature Communications, 2022
Therapeutic antibody development requires selection and engineering of molecules with high affinity and other drug-like biophysical properties. Co-optimization of multiple antibody properties remains a difficult and time-consuming process that impedes ...
Emily K. Makowski, Patrick C. Kinnunen, Jie Huang, Lina Wu, Matthew D. Smith, Tiexin Wang, Alec A. Desai, Craig N. Streu, Yulei Zhang, J. Zupancic, J. Schardt, J. Linderman, Peter M. Tessier   +12 more
semanticscholar   +1 more source

Antibody i-Patch prediction of the antibody binding site improves rigid local antibody-antigen docking [PDF]

Protein Engineering Design and Selection, 2013
Antibodies are a class of proteins indispensable for the vertebrate immune system. The general architecture of all antibodies is very similar, but they contain a hypervariable region which allows millions of antibody variants to exist, each of which can bind to different molecules.
Krawczyk, K, Baker, T, Shi, J, Deane, C
openaire   +3 more sources

SARS-CoV-2 receptor-binding mutations and antibody contact sites [PDF]

Antibody Therapeutics, 2021
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations can impact infectivity, viral load, and overall morbidity/mortality during infection. In this analysis, we look at the mutational landscape of the SARS-CoV-2 receptor-binding domain, a structure that is antigenic and allows for viral binding to the host.
Mejdani, Marios, Haddadi, Kiandokht, Pham, Chester, Mahadevan, Radhakrishnan   +3 more
openaire   +2 more sources

Insights into neutralization of animal viruses gained from study of influenza virus [PDF]

, 1991
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Colonno, Dimmock, Eisenlohr, Kennedy-Stoskopf, Kjellen, Kukuhara, Lamb, M. C. Outlaw, Mandel, Mandel, Mandel, McClure, N. J. Dimmock, Svehag, Thomas, Thomas, Viitala, Wharton   +17 more
core   +2 more sources

Structure Based Affinity Maturation and Characterizing of SARS-CoV Antibody CR3022 against SARS-CoV-2 by Computational and Experimental Approaches

Viruses, 2022
The COVID-19 epidemic is raging around the world. Neutralizing antibodies are powerful tools for the prevention and treatment of SARS-CoV-2 infection. Antibody CR3022, a SARS-CoV neutralizing antibody, was found to cross-react with SARS-CoV-2, but its ...
Wei Yu, Nan Zhong, Xin Li, Jiayi Ren, Yueming Wang, Chengming Li, Gui Yao, Rui Zhu, Xiaoli Wang, Zhenxing Jia, Changwen Wu, Rongfeng Chen, Weihong Zheng, Huaxin Liao, Xiaomin Wu, Xiaohui Yuan   +15 more
doaj   +1 more source

Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes [PDF]

, 2013
We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation.
Abe, Hiroshi, De Bock, Pieter-Jan, Fujiki, Saburo, Gevaert, Kris, Iwase, Shohei, Kuchitsu, Miyako, Ono, Shoichiro, Sato, Ryuhei, Tawada, Toshinobu, Yamagishi, Yuka   +9 more
core   +1 more source

A versatile design platform for glycoengineering therapeutic antibodies

mAbs, 2022
Manipulation of glycosylation patterns, i.e., glycoengineering, is incorporated in the therapeutic antibody development workflow to ensure clinical safety, and this approach has also been used to modulate the biological activities, functions, or ...
Seth D. Ludwig, Zachary J. Bernstein, Christian Agatemor, Kris Dammen-Brower, Jeffrey Ruffolo, Jonah M. Rosas, Jeremy D. Post, Robert N. Cole, Kevin J. Yarema, Jamie B. Spangler   +9 more
doaj   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Molecular anatomy of the antibody binding site.

Journal of Biological Chemistry, 1983
The binding region of immunoglobulins, which includes the portion of the molecule having the most variability in its amino acid sequence, is shown to have a surprisingly constant structure that can be characterized in terms of a simple, well-defined model.
J, Novotný, R, Bruccoleri, J, Newell, D, Murphy, E, Haber, M, Karplus   +5 more
openaire   +2 more sources

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources