Results 111 to 120 of about 2,663,361 (333)

Statistical mechanics of transcription-factor binding site discovery using Hidden Markov Models

, 2010
Hidden Markov Models (HMMs) are a commonly used tool for inference of transcription factor (TF) binding sites from DNA sequence data. We exploit the mathematical equivalence between HMMs for TF binding and the "inverse" statistical mechanics of hard rods
A. Drawid, A. Tanay, Anirvan M. Sengupta, D.J. Schwab, David J. Schwab, E. Schneidman, G. Stormo, H. Jeffreys, J.B. Kinney, L.E. Baum, M. Djordjevic, M. Weigt, N. Halabi, O.G. Berg, P. Mahalanobis, Pankaj Mehta, R. Olsen, S. Sinha, T. Mora   +18 more
core   +1 more source

Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action [PDF]

, 2022
K. V. Grzhegorzhevskii, М. О. Тонкушина, П. А. Гущин, I.D. Gagarin, Alexander Ermoshin, Kseniya Belova, Anna Prokofyeva, А. А. Остроушко, Alexander S. Novikov   +8 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Predicting the biological activity of selected phytochemicals in Alsophila spinulosa leaves against 4-aminobutyrate-aminotransferase: A potential antiepilepsy agents

Eclética Química
The use of medicinal plants as an alternative mean of treating various diseases has drawn the attention of several researchers. The desire to find lasting solutions to epilepsy among humans increases every day.
Oyebamiji Abel Kolawole, Olujinmi Faith Eniola, Akintelu Sunday Adewale, Adetuyi Babatunde, Ogunlana Olubanke, Semire Banjo, Akintayo Emmanuel Temitope, Akintayo Cecilia Olufunke, Babalola Jonathan Oyebamiji, Olawoye Bolanle Mary, Aworinde Juliana Oluwasayo   +10 more
doaj   +1 more source

Measuring similarities between transcription factor binding sites

BMC Bioinformatics, 2005
Background Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profiles complicate large scale analysis of transcription factor binding sites ...
Gonze Didier, Kielbasa Szymon M, Herzel Hanspeter   +2 more
doaj   +1 more source

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery [PDF]

, 2015
Yuxi Wang, Hang Zhang, Benoı̂t Gigant, Yamei Yu, Yangping Wu, Xi Chen, Qinhuai Lai, Zhao-ya Yang, Qiang Chen, Jinliang Yang   +9 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin α1 [PDF]

, 2011
Kaylen Lott, Anshul Bhardwaj, Peter J. Sims, Gino Cingolani   +3 more
openalex   +1 more source

FTMove: A Web Server for Detection and Analysis of Cryptic and Allosteric Binding Sites by Mapping Multiple Protein Structures

, 2022
Megan Egbert, George Jones, Matthew Collins, Dima Kozakov, Sándor Vajda   +4 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source