Results 131 to 140 of about 8,324,980 (383)
High-affinity binding sites involved in the import of porin into mitochondria [PDF]
, 1987 The specific recognition by mitochondria of the precursor of porin and the insertion into the outer membrane were studied with a radiolabeled water-soluble form of porin derived from the mature protein.
Neupert, Walter, Pfaller, Rupert
core +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
High-throughput identification of interacting protein-protein binding sites
BMC Bioinformatics, 2007 Background With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces.
Wang Wei, Chung Jo-Lan, Bourne Philip E
doaj +1 more source
Statistical mechanics of transcription-factor binding site discovery using Hidden Markov Models
, 2010 Hidden Markov Models (HMMs) are a commonly used tool for inference of transcription factor (TF) binding sites from DNA sequence data. We exploit the mathematical equivalence between HMMs for TF binding and the "inverse" statistical mechanics of hard rods
A. Drawid +18 more
core +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
LOCATION AND ROLE OF STEROL AT NYSTATIN-BINDING SITES [PDF]
, 1962 J. O. Lampen +3 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Metal-binding sites of concanavalin A and their role in the binding of α-methyl
, 1968 A. Joseph Kalb, Alexander Levitzki
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE [PDF]
, 1962 R.C. Hughes +2 more
openalex +1 more source