Results 141 to 150 of about 1,488,373 (296)

Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors

, 2012
Masoumeh Alipour, Mehdi Khoobi, Alireza Foroumadi, Hamid Nadri, Alireza Moradi, Amirhossein Sakhteman, Mehdi Ghandi, Abbas Shafiee   +7 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes. [PDF]

Acta Crystallogr F Struct Biol Commun
Weyand M, Quast L, Steegborn C.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mapping transcription factor binding sites by learning UV damage fingerprints. [PDF]

Nucleic Acids Res
Wilson HE, Stevison S, Lamprey L, Wyrick JJ.   +3 more
europepmc   +1 more source

Synthesis of Nitroindole Derivatives with High Affinity and Selectivity for Melatoninergic Binding Sites MT₃

, 2002
Véronique Leclerc, Saı̈d Yous, Philippe Delagrange, Jean A. Boutin, Pierre Renard, Daniel Lesieur   +5 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multiple overlapping binding sites determine transcription factor occupancy. [PDF]

Nature
Khetan S, Carroll BS, Bulyk ML.
europepmc   +1 more source

Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

, 2012
Gamma Chi, Alexandra Manos‐Turvey, P. D. T. O’Connor, Jodie M. Johnston, Genevieve L. Evans, Edward N. Baker, Richard J. Payne, J. Shaun Lott, Esther M. M. Bulloch   +8 more
openalex   +1 more source

Diffusion of target cell membrane proteins allows recognition of cryptic binding sites by Mycoplasma pulmonis hemagglutinin [PDF]

, 1985
F. Chris Minion, Jon D. Goguen
openalex   +1 more source