Results 151 to 160 of about 1,507,897 (295)

Characterization of EPPIN's Semenogelin I Binding Site: A Contraceptive Drug Target1

, 2020
Erick J. R. Silva, Katherine G. Hamil, Richard T. Richardson, Michael G. O’Rand   +3 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Comparison of Human and Canine P-Glycoprotein Substrates at R, P, and H Binding Sites. [PDF]

J Vet Pharmacol Ther
Burke NS, Mealey KL.
europepmc   +1 more source

Deletion of the short N‐terminal extension in OCP reveals the main site for FRP binding [PDF]

, 2017
Nikolai N. Sluchanko, Yury B. Slonimskiy, Marcus Moldenhauer, Thomas Friedrich, Eugene G. Maksimov   +4 more
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

SwinSite: 3D Structure-Based Prediction of Protein-Ligand Binding Sites Using a Combined Vision Transformer and Convolution Model. [PDF]

J Chem Inf Model
Kim D, Lee J.
europepmc   +1 more source

Structure of the fibrinogen γ‐chain integrin binding and factor XIIIa cross‐linking sites obtained through carrier protein driven crystallization [PDF]

, 1999
Scott Ware, W.F. Anderson, John P. Donahue, Jacek Hawiger   +3 more
openalex   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells. [PDF]

Nucleic Acids Res
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L.   +7 more
europepmc   +1 more source

Uncovering the Transmembrane Metal Binding Site of the Novel Bacterial Major Facilitator Superfamily-Type Copper Importer CcoA [PDF]

, 2016
Bahia Khalfaoui-Hassani, Andreia F. Veríssimo, H Koch, Fevzi Daldal   +3 more
openalex   +1 more source