Results 171 to 180 of about 8,324,980 (383)

Structure of the antithrombin-binding site in heparin. [PDF]

, 1979
Ulf Lindahl, G. Bäckström, Magnus Höök, L Thunberg, L Å Fransson, Alfred Linker   +5 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

RNA-RNA interactions in the binding site of protein L24 on 23S ribosomal RNA of E. coli II. Sequence analysis of the interacting fragments [PDF]

, 1978
Alain Krol, Mohamed Ali Machatt, Christiane Branlant, J.P. Ebel   +3 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Ultrastructural localization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs. [PDF]

, 1975
Garth L. Nicolson, Ryuzo Yanagimachi, Hiroko Yanagimachi   +2 more
openalex   +1 more source

Mapping genome-wide transcription-factor binding sites using DAP-seq

Nature Protocols, 2017
Anna Bartlett, Ronan C. O’Malley, S. Huang, M. Galli, Joseph R. Nery, A. Gallavotti, J. Ecker   +6 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Studies on the binding of tritiated p-dimethylaminoazobenzene in rat liver and the role of intranuclear binding sites in the early stages of carcinogenesis

, 1965
K. R. Rees, G. F. Rowland, J S Varcoe
openalex   +1 more source

Evidence for an Ester Linkage between the Labile Binding Site of C3b and Receptive Surfaces [PDF]

, 1979
S.K. Alex Law, N A Lichtenberg, R. P. Levine   +2 more
openalex   +1 more source