Results 231 to 240 of about 1,507,897 (295)

Recent computational advances in the identification of cryptic binding sites for drug discovery. [PDF]

Bioinform Adv
Gašparíková D, Chikhale R, Cole J, Pohl E.   +3 more
europepmc   +1 more source

Binding of Tn3 Resolvase to Its Resolution Site [PDF]

, 1993
David Gordon Blake
openalex  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites. [PDF]

Mol Cancer Ther
Wu T, Yang Z, Tang S, Yuan H, Liu Y, Li H, Liu N, Huang Z, Chen Y, Zhou Z.   +9 more
europepmc   +1 more source

Above-Filter Digestion Proteomics Reveals Drug Targets and Localizes Ligand Binding Site

Bohdana Sokolova, Hassan Gharibi, Maryam Jafari, Hezheng Lyu, Silvia Lovera, Hoor Ayub, Amir Ata Saei, Roman A Zubarev   +7 more
openalex   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Simultaneous ligand binding to intact and partially formed ATP-binding sites in the hexameric termination factor Rho. [PDF]

J Biol Chem
Billings TD, Baker K, Lacey P, Benedek MJ, Muzquiz R, Wysocki VH, Foster MP.   +6 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Identifying 14-3-3 interactome binding sites with deep learning.

Digit Discov
van Weesep L, Özçelik R, Pennings M, Criscuolo E, Ottmann C, Brunsveld L, Grisoni F.   +6 more
europepmc   +1 more source

Accurate prediction of protein-ATP binding sites based on a protein pretrained large language model and a fractional-order convolutional neural network. [PDF]

Sci Rep
Guo M, Tu Y, Yu J, Wang Y.
europepmc   +1 more source