Results 231 to 240 of about 2,663,361 (333)

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor

Herman D. Lim, Damian Bartuzi, Alastair C. Keen, Caroline Rauffenbart, Jacqueline R. Glenn, Steven J. Charlton, Silvia Lovera, Zara A. Sands, Ali Ates, Martyn Wood, Meritxell Canals, Jonathan A. Javitch, Jens Carlsson, J. Robert Lane   +13 more
openalex   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Identification of druggable binding sites and small molecules as modulators of TMC1. [PDF]

Commun Biol
De-la-Torre P, Martínez-García C, Gratias P, Mun M, Santana P, Akyuz N, González W, Indzhykulian AA, Ramírez D.   +8 more
europepmc   +1 more source

Crystal Structures of the Mnk2 Kinase Domain Reveal an Inhibitory Conformation and a Zinc Binding Site

, 2005
Ralf Jauch, Stefan Jäkel, Catharina Netter, Kay Schreiter, Babette Aicher, Herbert Jäckle, M.C. Wahl   +6 more
openalex   +2 more sources

Computational study of Cu²⁺, Fe²⁺, Fe³⁺, Mn²⁺ and Mn³⁺ binding sites identification on HSA 4K2C

, 2020
Syahputra Wibowo, Sutiman Bambang Sumitro, Sri Widyarti   +2 more
openalex   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Identifying 14-3-3 interactome binding sites with deep learning.

Digit Discov
van Weesep L, Özçelik R, Pennings M, Criscuolo E, Ottmann C, Brunsveld L, Grisoni F.   +6 more
europepmc   +1 more source

InDeepNet: a web platform for predicting functional binding sites in proteins using InDeep. [PDF]

Nucleic Acids Res
Mareuil F, Torchet R, Ruano LC, Mallet V, Nilges M, Bouvier G, Sperandio O.   +6 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Fine tuning wheat heading time through genome editing of transcription factor binding sites in Ppd-1 gene promoter. [PDF]

Sci Rep
Kiseleva AA, Timonova EM, Berezhnaya AA, Kolozhvari AE, Kochetov AV, Salina EA.   +5 more
europepmc   +1 more source