Results 261 to 270 of about 1,488,373 (296)
Some of the next articles are maybe not open access.
1996
This chapter assesses advances in the understanding and manipulation of antibody binding sites and variable regions. The antigen binding region of an antibody reduced to a 25-kDa minimum comprises of a noncovalent heterodimer of V H and V L domains.
J S, Huston, M N, Margolies, E, Haber
openaire +2 more sources
This chapter assesses advances in the understanding and manipulation of antibody binding sites and variable regions. The antigen binding region of an antibody reduced to a 25-kDa minimum comprises of a noncovalent heterodimer of V H and V L domains.
J S, Huston, M N, Margolies, E, Haber
openaire +2 more sources
Current Opinion in Biotechnology, 1992
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
J A, Tainer, V A, Roberts, E D, Getzoff
openaire +2 more sources
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
J A, Tainer, V A, Roberts, E D, Getzoff
openaire +2 more sources
Peripheral benzodiazepine binding sites
Pharmacology & Therapeutics, 1989Article de synthese sur les sites de fixation peripheriques des benzodiazepines: distribution, fixation biologique, action au niveau du systeme nerveux central, regulation par le GABA et le stress, regulation endocrine, relation avec les canaux calcium, autres ligands, role ...
V, Saano, L, Rägo, M, Räty
openaire +2 more sources
Journal of Neurochemistry, 1988
Abstract: The distribution and characterization of specific melatonin binding sites were studied using 125I‐melatonin. Autoradiography revealed only three sites of specific melatonin binding in brain: the suprachiasmatic nuclei, the median eminence, and the small part of choroid plexus at the caudal end of the fourth ventricle.
openaire +2 more sources
Abstract: The distribution and characterization of specific melatonin binding sites were studied using 125I‐melatonin. Autoradiography revealed only three sites of specific melatonin binding in brain: the suprachiasmatic nuclei, the median eminence, and the small part of choroid plexus at the caudal end of the fourth ventricle.
openaire +2 more sources
Brain leukotriene C4 binding sites are S-alkylglutathione binding sites
European Journal of Pharmacology, 1989Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-alkylglutathione binding sites ...
A M, Goffinet, A, Nguyen
openaire +2 more sources
Benzodiazepine-Binding Site and Gaba-Binding Site
1983There is a body of experimental evidence to suggest that the benzodiazepine-binding site, the GABA-binding site and the chloride ionophore are functionally correlated. To elucidate this issue, the interactions among these components in both membrane-bound state and soluble state are examined.
Li-ren Chang, Eric A. Barnard
openaire +1 more source
Anatomy of lipase binding sites: the scissile fatty acid binding site
Chemistry and Physics of Lipids, 1998Shape and physico-chemical properties of the scissile fatty acid binding sites of six lipases and two serine esterases were analyzed and compared in order to understand the molecular basis of substrate specificity. All eight serine esterases and lipases have similar architecture and catalytic mechanism of ester hydrolysis, but different substrate ...
J, Pleiss, M, Fischer, R D, Schmid
openaire +2 more sources
Hormone binding site of corticosteroid binding globulin
Nature Structural & Molecular Biology, 1995A new location for the hormone-binding site of corticosteroid binding globulin is propose based on experimental data, together with a sequence and structural alignment of the serpin ...
P, Edgar, P, Stein
openaire +2 more sources
What makes a binding site a binding site?
Current Opinion in Structural Biology, 1995Organic probe molecules have recently been used to define hydrophobic binding sites on the surface of proteins. It appears that the presence of water on the surface of a protein plays a crucial role in the interaction between that protein and its binding site.
openaire +2 more sources