Results 281 to 290 of about 2,663,361 (333)

Essential roles of CTCF binding sites at TAD boundaries in modulating chromatin interactions and transcriptional regulation at the <i>Ifng</i> locus. [PDF]

Front Immunol
Muto K, Yoshida D, Suzuki T, Yamamoto N, Inoue N, Murakami-Sekimata A, Iseki K, Sekimata M.   +7 more
europepmc   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Determination of silver(I)-binding sites in canonical B-DNA by NMR spectroscopy. [PDF]

J Biol Inorg Chem
Lenz T, Javornik U, Hebenbrock M, Plavec J, Müller J.   +4 more
europepmc   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

CryptoBench: cryptic protein-ligand binding sites dataset and benchmark. [PDF]

Bioinformatics
Škrhák V, Novotný M, Feidakis CP, Krivák R, Hoksza D.   +4 more
europepmc   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Novel Anopheles glutamate-gated chloride ion channel binding sites facilitate ivermectin mosquito-lethal effect

Nguyen MN, Jones AK, Hotwagner D, Khemrattrakool P, Hongsuwong T, Hanboonkunupakarn B, Jittamala P, Sriwichai P, Tarning J, Kobylinski KC.   +9 more
europepmc   +1 more source

Comparative evaluation of methods for the prediction of protein-ligand binding sites. [PDF]

J Cheminform
Utgés JS, Barton GJ.
europepmc   +1 more source

Preliminary assessment of the therapeutic potential of staphylococcal enterotoxin-like W via biological activity and TCR binding sites analysis. [PDF]

Virulence
Yang Y, Wei X, Meng F, Gong Y, Guo Y, Long L, Fan J, Zhao Y, Wang W, Xiao D, Wang L, Zhang M, Hu D, Zhang J, Yan X.   +14 more
europepmc   +1 more source