Results 191 to 200 of about 268,312 (268)

Antibacterial activity, phytochemical profiling and ADMET prediction of bioactive compounds in Origanum syriacum and Salix alba. [PDF]

Sci Rep
Basudan NS, El-Hefnawy AA, El-Sapagh S, El-Sayed MN, Saad-Allah KM, Azab M.   +5 more
europepmc   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source

Bioactive Compounds and Therapeutic Potential of Plant Buds: Current Evidence and Future Perspectives of Gemmotherapy. [PDF]

Molecules
Tomczyk M, Dżugan M.
europepmc   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

IRACEMA: A Database Management System for Bioactive Compounds Obtained and Characterized by Brazilian Researchers. [PDF]

ACS Omega
Lourenço TA, Costa RPO, Melo LFM, Ferreira UA, Alves EHP, Oliveira-Filho LP, Scotti L, Scotti MT, Trossini GHG.   +8 more
europepmc   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Plant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection. [PDF]

Curr Issues Mol Biol
Zhu L, Li M, Wei D, Zhou L.
europepmc   +1 more source

Nanopore‐Based Protein Deceleration and Sensing Using Graphene/Si3N4 Dual Membrane Cavity

Advanced Science, EarlyView.
A graphene/Si3N4 dual membrane cavity system achieves multi‐stage protein deceleration through spatial geometry. Multi‐level current traces provide high‐resolution spatial localization and early warning signals. ABSTRACT Sequencing of protein with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost, and portability.
Yubin Cao, Junzhou He, Wei Si
wiley   +1 more source