Results 21 to 30 of about 43,422 (268)

Mesoporous bioactive glass composition effects on degradation and bioactivity

Bioactive Materials, 2021
Mesoporous bioactive glasses (MBGs) are promising materials for regenerative medicine, due to their favorable properties including bioactivity and degradability. These key properties, but also their surface area, pore structure and pore volume are strongly dependent on synthesis parameters and glass stoichiometry.
Schumacher, M., Habibovic, P., van Rijt, S.   +2 more
openaire   +4 more sources

Chemical Composition and Bioactive Characterisation of Impatiens walleriana

Molecules, 2021
The attractive colour characteristics of the flowers of the species Impatiens walleriana have been arousing great interest in the food industry, which is looking for potential natural sources of colouring ingredients.
Eleomar de O. Pires, Eliana Pereira, Carla Pereira, Maria Inês Dias, Ricardo C. Calhelha, Ana Ćirić, Marina Soković, Gustavo Hassemer, Carolina Castilho Garcia, Cristina Caleja, Lillian Barros, Isabel C. F. R. Ferreira   +11 more
doaj   +1 more source

Screening bioactivity and bioactive constituents of Nordic unifloral honeys [PDF]

Food Chemistry, 2017
The objective of this study was to screen the antibacterial and antioxidant activity of thirty nine honey samples from Finland, Sweden, Norway and Denmark. Their physicochemical properties were analysed, antioxidant activity was evaluated by DPPH assay and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus was assessed by ...
Tammela Päivi Sirpa Marjaana, Salonen Anneli, Fauch Laure Stephanie, Julkunen-Tiitto Riitta, Virjamo Virpi   +4 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Targeting PI3K signaling in Lung Cancer: advances, challenges and therapeutic opportunities

Journal of Translational Medicine
Lung cancer remains the leading cause of cancer-related mortality globally, necessitating the continual exploration of novel therapeutic targets.
Bitian Zhang, Ping-Chung Leung, William Chi-Shing Cho, Chun-Kwok Wong, Dongjie Wang   +4 more
doaj   +1 more source

Artemisinin and Its Derivatives as Potential Anticancer Agents

Molecules
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. (qinghao). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment ...
Luan Wen, Ben Chung-Lap Chan, Ming-Hua Qiu, Ping-Chung Leung, Chun-Kwok Wong   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection

Environmental Sciences Europe
Aristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers.
Bitian Zhang, Ping-Chung Leung, Chun-Kwok Wong, Dongjie Wang   +3 more
doaj   +1 more source

Dactylospongia elegans—A Promising Drug Source: Metabolites, Bioactivities, Biosynthesis, Synthesis, and Structural-Activity Relationship

Marine Drugs, 2022
Marine environment has been identified as a huge reservoir of novel biometabolites that are beneficial for medical treatments, as well as improving human health and well-being.
Sabrin R. M. Ibrahim, Sana A. Fadil, Haifa A. Fadil, Rawan H. Hareeri, Sultan O. Alolayan, Hossam M. Abdallah, Gamal A. Mohamed   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source