Results 21 to 30 of about 43,707 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Targeting PI3K signaling in Lung Cancer: advances, challenges and therapeutic opportunities

Journal of Translational Medicine
Lung cancer remains the leading cause of cancer-related mortality globally, necessitating the continual exploration of novel therapeutic targets.
Bitian Zhang, Ping-Chung Leung, William Chi-Shing Cho, Chun-Kwok Wong, Dongjie Wang   +4 more
doaj   +1 more source

Artemisinin and Its Derivatives as Potential Anticancer Agents

Molecules
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. (qinghao). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment ...
Luan Wen, Ben Chung-Lap Chan, Ming-Hua Qiu, Ping-Chung Leung, Chun-Kwok Wong   +4 more
doaj   +1 more source

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

EXCLI journal, 2011
EXCLI Journal ; Vol.
Kiatfuengfoo, Rachada, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Suksrichavalit, Thummaruk, Treeratanapiboon, Lertyot, Worachartcheewan, Apilak   +6 more
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Aristolochic acid I orchestrates multi-organ carcinogenesis through apoptotic pathway in bladder, kidney, and liver cancers: a multi-omics dissection

Environmental Sciences Europe
Aristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers.
Bitian Zhang, Ping-Chung Leung, Chun-Kwok Wong, Dongjie Wang   +3 more
doaj   +1 more source

Dactylospongia elegans—A Promising Drug Source: Metabolites, Bioactivities, Biosynthesis, Synthesis, and Structural-Activity Relationship

Marine Drugs, 2022
Marine environment has been identified as a huge reservoir of novel biometabolites that are beneficial for medical treatments, as well as improving human health and well-being.
Sabrin R. M. Ibrahim, Sana A. Fadil, Haifa A. Fadil, Rawan H. Hareeri, Sultan O. Alolayan, Hossam M. Abdallah, Gamal A. Mohamed   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Agree to disagree: The contradiction between IL-18 and IL-37 reveals shared targets in cancer

Pharmacological Research
IL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological homeostasis.
Dongjie Wang, Bitian Zhang, Xiaolin Liu, Lea Ling-Yu Kan, Ping-Chung Leung, Chun-Kwok Wong   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source