Results 41 to 50 of about 82,505 (314)
Artemisinin and Its Derivatives as Potential Anticancer Agents
MoleculesArtemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. (qinghao). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment ...
Luan Wen +4 more
doaj +1 more source
Phytochemical study of a species with ethnopharmacological interest. Sideritis romana L. [PDF]
, 2016 The phytochemical analysis of Sideritis romana L., a species largely used as a traditional remedy, led to the isolation and the identification of several acetylated flavonoid glycosides with apigenin, luteolin, hypolaetin and isoscutellarein backbone ...
BIANCO, Armandodoriano +5 more
core +1 more source
Screening bioactivity and bioactive constituents of Nordic unifloral honeys [PDF]
Food Chemistry, 2017 The objective of this study was to screen the antibacterial and antioxidant activity of thirty nine honey samples from Finland, Sweden, Norway and Denmark. Their physicochemical properties were analysed, antioxidant activity was evaluated by DPPH assay and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus was assessed by ...
Tammela Päivi Sirpa Marjaana +4 more
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Environmental Sciences EuropeAristolochic acid I (AA-I), a naturally occurring compound derived from plants of the genus Aristolochia, is a well-documented nephrotoxin and carcinogen linked to bladder (BLCA), kidney (KIRC), and liver (LIHC) cancers.
Bitian Zhang +3 more
doaj +1 more source
Marine Drugs, 2022 Marine environment has been identified as a huge reservoir of novel biometabolites that are beneficial for medical treatments, as well as improving human health and well-being.
Sabrin R. M. Ibrahim +6 more
doaj +1 more source
Recovery of Polyphenols from Brewer’s Spent Grains [PDF]
, 2019 peer-reviewedThe recovery of antioxidant polyphenols from light, dark and mix brewer’s spent grain (BSG) using conventional maceration, microwave and ultrasound assisted extraction was investigated.
Birsan, Rares +3 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Agree to disagree: The contradiction between IL-18 and IL-37 reveals shared targets in cancer
Pharmacological ResearchIL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological homeostasis.
Dongjie Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source