Results 31 to 40 of about 43,422 (268)

Agree to disagree: The contradiction between IL-18 and IL-37 reveals shared targets in cancer

Pharmacological Research
IL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological homeostasis.
Dongjie Wang, Bitian Zhang, Xiaolin Liu, Lea Ling-Yu Kan, Ping-Chung Leung, Chun-Kwok Wong   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Alkaloids Isolated from the Lateral Root of <em>Aconitum carmichaelii</em>

Molecules, 2012
Two new alkaloids, aconicarmine (<strong>1</strong>) and aconicaramide (<strong>5</strong>), were isolated from the EtOH extract of the lateral roots of <em>Aconitum carmichaelii</em>, together with five known ...
Qin-Mei Zhou, Ou Dai, Feng Wan, Zhao Geng, Cheng-Jun He, Li Guo, Cheng Peng, Xiao-Fang Xie, Liang Xiong   +8 more
doaj   +1 more source

Structure and Bioactivities of a Novel Polysaccharide Extracted From Dendrobium huoshanense by Subcritical Water

Frontiers in Nutrition, 2022
In this study, the polysaccharide was extracted by subcritical water from Dendrobium huoshanense. A novel polysaccharide (DHPs-1) was obtained through several purification steps and its structure and bioactivity were investigated.
Li Wang, Li Wang, Yi-gui Mao, Xiang Zeng, Na Liu, Chao-fei Niu, Xin-xin Li, Bing-ji Ma, Lan-ping Guo, Xiao-long Yang   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

“Malancha” [Alternanthera philoxeroides (Mart.) Griseb.]: A Potential Therapeutic Option against Viral Diseases

Biomolecules, 2022
Alternanthera philoxeroides (Mart.) Griseb., commonly known as “Alligator weed” in English, and “Malancha” in Bengali, is a leafy vegetable from the family Amaranthaceae A. L. de Jussieu.
Lutfun Nahar, Sushmita Nath, Satyajit D. Sarker   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Recent advances in Polygonaceae endophytes: diversity, secondary metabolites and biotechnological applications

Frontiers in Bioengineering and Biotechnology
The Polygonaceae family comprises numerous traditional Chinese medicinal herbs and serves as a significant source of natural products with bioactive properties. Endophytes, which colonize the internal tissues of plants, have various beneficial effects on
Zhi-Min Chen, Rui-Qi Tang
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Impacts of Six Methods of Extraction on Physicochemical Properties, Structural Characteristics and Bioactivities of Polysaccharides from Pholiota nameko Residue

Foods
By integrating waste valorization with green extraction, in the current study, the impacts of distinct extraction methods on the extraction yield, structural characterization, in vitro antioxidant abilities and in vitro immunomodulatory activity of ...
Jingbo Zhang, Yajing Bai, Xiaoxue Zhang, Yiyao Wang, Zongshu Li, Chengguang He, Lili Guan   +6 more
doaj   +1 more source