Results 71 to 80 of about 3,487,707 (291)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Gastrointestinal endogenous proteins as a source of bioactive peptides : Doctor of Philosophy in Nutritional Sciences at Riddet Institute, Massey University, Palmerston North, New Zealand [PDF]

, 2016
Gastrointestinal endogenous proteins (GEP) were investigated as a source of bioactive peptides. In silico and in vitro methods were used singly or in combination to study GEP-derived peptides after simulated digestion.
Acharya, Prasannalakshmi
core  

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
A Boëdec, A Matsushima, A Reichenberg, AC Brown, AC Hayday, AC Hayday, Amanda C. Brown, B Altincicek, B Moser, Bernhard Moser, C Agrati, C Belmant, C De Santo, C Münz, CC Szeto, Chan-Yu Lin, CM Bunke, Colin Hill, Cormac G. M. Gahan, CT Morita, CT Spencer, CT Weaver, D Vermijlen, David W. Johnson, DI Godfrey, DJ Pennington, DK Kim, E Oldfield, E. John Wherry, F Annunziato, F Dieli, F Sallusto, G Sarikonda, Gareth W. Roberts, GW Roberts, H Jomaa, H Jomaa, H Li, H Wang, H Wei, I Müller, J Feurle, J Mookerjee-Basu, James A. Chess, JF Bukowski, JJ O'Shea, John D. Williams, JS Savill, K Pietschmann, KJ Puan, KK Kumarasamy, KM Murphy, L Troidle, M Begley, M Begley, M Blunden, M Bonneville, M Brandes, M Eberl, M Eberl, M Eberl, M Eberl, M Eberl, M Fahim, M Kistowska, M Krishnan, M Pelletier, M Rohmer, MA Missinou, Mark A. Toleman, Martin S. Davey, Matthias Eberl, MC Devilder, MC Devilder, MI Hirsh, MJ Llewelyn, N Nathan, N Topley, Nicholas Topley, O Devuyst, P Choi, P Constant, PS Evans, R Medzhitov, RE Rojas, RM McLoughlin, S Amslinger, S Mujais, Simon J. Davies, Sinéad Heuston, SJ Davies, SM Hurst, SR Gill, T Ganz, Tanya Parish, TR Walsh, TW Rice, W Holtmeier, Y Kato, Y Neu, Y Tanaka, Y Zhang   +101 more
core   +5 more sources

Molecular Docking Studies, Bioactivity Score Prediction, Drug Likeness Analysis of GSK-3 β Inhibitors: A Target Protein Involved in Alzheimer’s Disease

Biosciences, Biotechnology Research Asia, 2018
Glycogen synthase kinase 3 β (GSK-3 Beta) is a potential target for developing an effective therapeutic effect in Alzheimer's disease (AD). Currently, no such drug or molecules has been found till date which can cure AD completely. Few drugs such as acetylcholinesterase inhibitors and memantine are ineffective in the later stages of the disease ...
Akanksha Joshi, Rajesh Kumar, Archit Sharma   +2 more
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources

Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study

Journal of Chemical Information and Modeling, 2021
Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today considered the main cause of cardiotoxicity in postmarketing surveillance.
T. Creanza, Pietro Delre, N. Ancona, G. Lentini, M. Saviano, G. Mangiatordi   +5 more
semanticscholar   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

The EVA spectral descriptor [PDF]

, 2000
The EVA descriptor is derived from fundamental IR- and Raman range molecular vibrational frequencies. EVA is sensitive to 3D structure but has an advantage over field-based 3D-QSAR methods inasmuch as it is invariant to both translation and rotation of ...
Turner, D.B., Willett, P.
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source