Interactions of grapefruit juice with drugs [PDF]
, 2001 Interactions between grapefruit juice and oral drugs have been reported in the literature. The constituents of the juice that give rise to pharmacokinetic interactions have not been identified with certainty. It has been suggested that the mechanisms may
Forte, John Stephen
core
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]
, 2016 The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar +5 more
core +2 more sources
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol
International Journal of Molecular Sciences, 2019 Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts.
A. Chimento +7 more
semanticscholar +1 more source
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
Advanced Healthcare Materials, EarlyView.This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold +2 more
wiley +1 more source
An Efficient Genetic Programming System with Geometric Semantic Operators and its Application to Human Oral Bioavailability Prediction [PDF]
arXiv, 2012 Very recently new genetic operators, called geometric semantic operators, have been defined for genetic programming. Contrarily to standard genetic operators, which are uniquely based on the syntax of the individuals, these new operators are based on their semantics, meaning with it the set of input-output pairs on training data.
arxiv
Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
core +1 more source
Advanced Healthcare Materials, EarlyView.To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao +8 more
wiley +1 more source
Use of isotope dilution method to predict bioavailability of organic pollutants in historically contaminated sediments. [PDF]
, 2014 Many cases of severe environmental contamination arise from historical episodes, where recalcitrant contaminants have resided in the environment for a prolonged time, leading to potentially decreased bioavailability.
Bao, Lian-Jun +4 more
core +2 more sources