Results 51 to 60 of about 803,201 (379)
Dietary Curcumin: Correlation between Bioavailability and Health Potential
Nutrients, 2019 The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and ...
M. Dei Cas, R. Ghidoni
semanticscholar +1 more source
Cyclosporine Absorption Following Orthotopic Liver Transplantation [PDF]
, 1986 Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption.
Beveridge +20 more
core +2 more sources
Frontiers in PharmacologyPhenytoin is a first-line antiepileptic drug with narrow therapeutic range and follows non-linear pharmacokinetics. Pharmacokinetics of phenytoin have been studied in plasma matrix before, however, there were several disadvantages.
Yahdiana Harahap +3 more
doaj +1 more source
Molecules, 2019 Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases.
K. Kawabata, Yasukiyo Yoshioka, J. Terao
semanticscholar +1 more source
Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review [PDF]
, 2015 Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively ...
Battino, Maurizioeditor +4 more
core +3 more sources
Role of the Encapsulation in Bioavailability of Phenolic Compounds
Antioxidants, 2020 Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc.
Josip Grgić +4 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches
International Journal of Molecular SciencesThe bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical development, significantly impacting therapeutic efficacy and commercial viability.
Ke Wu +6 more
semanticscholar +1 more source
Antioxidants, 2020 Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological ...
P. Cosme +3 more
semanticscholar +1 more source