Results 71 to 80 of about 719,874 (416)

Carbohydrate bioavailability [PDF]

open access: yesBritish Journal of Nutrition, 2005
There is consensus that carbohydrate foods, in the form of fruit, vegetables and whole-grain products, are beneficial to health. However, there are strong indications that highly processed, fibre-depleted, and consequently rapidly digestible, energy-dense carbohydrate food products can lead to over-consumption and obesity-related diseases.
Klaus N, Englyst, Hans N, Englyst
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Research Note: Effects of organic zinc on broiler intestinal permeability and integrity in Clostridium perfringens–challenged condition

open access: yesPoultry Science, 2020
This study evaluates the effects of a zinc–amino acid complex on broiler's intestinal permeability and integrity challenged with Clostridium perfringens.
Jingjing Sun, Cheng Zhang, Bingkun Zhang
doaj  

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]

open access: yes, 2016
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S   +4 more
core   +2 more sources

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

open access: yesAging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective.

open access: yesComprehensive Reviews in Food Science and Food Safety, 2018
Flavonoids are plant-derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and the complex pathways involved in bioavailability of flavonoids in the human body are now well ...
G. Williamson, C. Kay, A. Crozier
semanticscholar   +1 more source

Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems.

open access: yesComprehensive Reviews in Food Science and Food Safety, 2020
Nowadays, many consumers prefer foods with a high content of nutraceuticals that contribute to the prevention or healing of chronic diseases. Therefore, in recent years, more and more researchers have studied the bioefficiency, safety, and toxicity of ...
C. Dima   +3 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

Complete dataset for 2-treatment, 2-sequence, 2-period efavirenz bioequivalence study conducted with nightly dosing

open access: yesData in Brief, 2016
The efavirenz pharmacokinetic raw data presented in this article was obtained in an average bioequivalence study between a local brand and Stocrin (Merck Sharp & Dohme, purchased from Australia, batch H009175, expiration date November 2013).
Manuel Ibarra   +4 more
doaj  

Validating the chronic Pb algae bioavailability model at high pH : single-species evaluation : final report, 12 June 2017 [PDF]

open access: yes, 2017
We investigated toxicity of Pb to Pseudokirchneriella subcapitata using the standard 72h-growth inhibition assays at 2 pH levels (pH 7.2 & pH 8.4) and 2 P (P 10 ug/L & P 100 ug/L) levels, i.e. at 4 treatments in total.
De Schamphelaere, Karel, Nys, Charlotte
core   +1 more source

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