Results 201 to 210 of about 54,975 (247)

Strategies for enhancing the oral bioavailability of cannabinoids

Expert Opinion on Drug Metabolism & Toxicology, 2022
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first and most critical barrier.
Ayala, Bar-Hai, Abraham J, Domb, Amnon, Hoffman   +2 more
openaire   +2 more sources

Enhancement of hydralazine bioavailability by food

Clinical Pharmacology & Therapeutics, 1977
The influence of food on the bioavailability of hydralazine in noncoated and coated tablets was examined in 5 healthy males. Each subject received an oral 50‐mg dose on four different occasions: two 25‐mg noncoated tablets with and without food and one 50‐mg coated tablet with and without food.
A, Melander, K, Danielson, A, Hanson, B, Rudell, B, Scherstén, T, Thulin, E, Wåhlin   +6 more
openaire   +2 more sources

Enhancement of ampicillin bioavailability in pigs

Journal of Veterinary Pharmacology and Therapeutics, 1979
Biliary excretion of Na‐ampicillin was studied in 40–50 kg male castrated pigs fitted with a bile duct re‐entrant cannula. There is a low recovery of antibiotic in the bile after an extraduodenal administration. The injection of sodium de‐hydrocholate increased the bioavailability of ampicillin and decreased the volumes of distribution in the drug. The
Galtier, Pierre, Alvinerie, M.
openaire   +2 more sources

Lipopolysaccharide Nanosystems for the Enhancement of Oral Bioavailability

AAPS PharmSciTech, 2021
Nanosystems that incorporate both polymers and lipids have garnered attention as emerging nanotechnology approach for oral drug delivery. These hybrid systems leverage on the combined properties of polymeric and lipid-based nanocarriers while eliminating their inherent limitations. In view of the safety-related benefits of naturally occurring polymers,
Mumuni, Sumaila, Thashree, Marimuthu, Pradeep, Kumar, Yahya E, Choonara   +3 more
openaire   +2 more sources

Bioavailability enhancement of glucosamine hydrochloride by chitosan

International Journal of Pharmaceutics, 2013
Glucosamine, as a dietary supplement for management of osteoarthritis, has a low and erratic oral bioavailability due to its transport-mediated absorption and presystemic loss in liver and GI tract. The present study described an effective approach to improve glucosamine intestinal absorption and hence its bioavailability using chitosan.
Shuai, Qian, Qizhi, Zhang, Yanfeng, Wang, Benjamin, Lee, Guru V, Betageri, Moses S S, Chow, Min, Huang, Zhong, Zuo   +7 more
openaire   +2 more sources

Enhancement of Bioavailability by Surfactants

1995
Bioavailability of apolar pollutants is investigated quantitatively using a theoretical and an experimental approach. Theoretical analysis suggests that enhancement of bioavailability can be achieved by an increase of the mass transfer rate. Some possibilities are given.
Breure, A.M., Volkering, F., Mulder, H., Rulkens, W.H., van Andel, J.G.   +4 more
openaire   +2 more sources

The utility of cyclodextrins for enhancing oral bioavailability

Journal of Controlled Release, 2007
Cyclodextrins (CD) have been utilized extensively in pharmaceutical formulations to enhance oral bioavailability. A critical review of the literature in which cyclodextrins were utilized for this purpose was conducted. The goal of this review was to determine if quantitative guidelines for drug and cyclodextrin properties necessary for bioavailability ...
Rebecca L, Carrier, Lee A, Miller, Imran, Ahmed   +2 more
openaire   +2 more sources

METHODS FOR ENHANCEMENT OF BIOAVAILABILITY

2022
Dr. Gufran Ajmal, Dr.
openaire   +1 more source

Overview of Metabolism and Bioavailability Enhancement of Polyphenols

Journal of Agricultural and Food Chemistry, 2013
A proper diet is one of major factors contributing to good health and is directly related to general condition of the organism. Phenolic compounds are abundant in foods and beverages (fresh and processed fruits and vegetables, leguminous plants, cereals, herbs, spices, tea, coffee, wine, beer) and their pleiotropic biological activities result in ...
Urszula, Lewandowska, Karolina, Szewczyk, Elżbieta, Hrabec, Anna, Janecka, Sylwia, Gorlach   +4 more
openaire   +2 more sources

Enhancement of the bioavailability of propranolol and metoprolol by food

Clinical Pharmacology & Therapeutics, 1977
The possible influence of food intake on the bioavailability of one nonselective and one cardioselective beta adrenoceptor antagonist, propranolol and metoprolol, was examined by serial determinations of the drug concentrations in blood of healthy subjects, taking single doses of the drugs both on an empty stomach and together with a standardized ...
A, Melander, K, Danielson, B, Scherstén, E, Wåhlin   +3 more
openaire   +2 more sources