Results 211 to 220 of about 991,955 (291)

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch. [PDF]

Pharmaceutics, 2019
Nair AB, Gupta S, Al-Dhubiab BE, Jacob S, Shinu P, Shah J, Morsy MA, SreeHarsha N, Attimarad M, Venugopala KN, Akrawi SH.   +10 more
europepmc   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine. [PDF]

RSC Adv, 2019
Wei Y, Zhang J, Zheng Y, Gong Y, Fu M, Liu C, Xu L, Sun CC, Gao Y, Qian S.   +9 more
europepmc   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source