Results 221 to 230 of about 54,975 (247)

Dissolution and bioavailability enhancement of glyburide

Toxicological & Environmental Chemistry, 2013
The solubility behavior of drug is one of the most challenging aspects in formulation development, as dissolution and absorption behaviors depend upon this property. The objective of this study was to improve the solubility, dissolution rate, and bioavailability of a poor water-soluble oral hypoglycemic drug glyburide by forming a fast disintegrating ...
Srinivas Reddy Devireddy, Prabhakar Reddy Veerareddy   +1 more
openaire   +1 more source

Enhanced Bioavailability by Orally Administered Sirolimus Nanocrystals

ACS Applied Bio Materials, 2019
Nanocrystallization can improve the dissolvability of insoluble medicines in water, making them easier to administer. In the present study, sirolimus (SRL) was nanocrystallized, and the transport mechanism and efficacy of both formulations were compared in vitro and in vivo. The results showed that the 120 nm sirolimus nanocrystals (SRL NCs) had better
Jianglong Kong, Kai Wu, Ying Ji, Kui Chen, Jiaxin Zhang, Hui Sun, Yuelan Liang, Wei Liang, Yanan Chang, Jenny Cheng, Junmao Tong, Juan Li, Gengmei Xing, Guogang Chen   +13 more
openaire   +2 more sources

Nanotechnology in the Advancement of Enhancing Bioavailability

International Scientific Journal of Engineering and Management
:The nanotechnology is defined as the science that deals with the manipulations of matter on a scale of 1 to 100 nanometers, where a material can exhibit unique properties; whereas the bioavailability is defined as the rate and extent to which an administered drug substance is absorber and becomes available at its intended biological site of action in ...
, Chanchal S. Ingle, Sanika S. Wasankar, Gaurav R. Kirdak   +2 more
openaire   +1 more source

Enhancement of Drug Bioavailability by Cyclodextrins

Starch - Stärke, 1981
AbstractThe reassuring results of toxicity of orally administered ß‐cyclodextrin and the realization of its industrial production opens a new way in the formulation of non‐parenteral drug preparations. It is assumed that the utilization of ß‐cyclodextrin in oral drug preparations will be a common process within a decade.
openaire   +1 more source

Octacosanol: Biological activities and bioavailability enhancement strategies

Food Chemistry
Octacosanol (C₂₈H₅₈O) is a natural long-chain fatty alcohol that has attracted increasing attention in recent years due to its multiple biological activities, including anti-fatigue, anti-inflammatory, hypolipidemic, and antioxidant effects. However, its extremely low bioavailability limits the exertion of its biological activity in vivo and hinders ...
Liwen, Liang, Xin Yi, Peng, Qiong, Xiao, Feifei, Zhong, Xiaoxi, Zeng, Wen, Li, Jing, Deng, Qinlu, Lin, Feijun, Luo, Qingming, Cao, Kilaza Samson, Mwaikono   +10 more
openaire   +2 more sources

Bioavailability and bioactivity enhancement by nanomization

2014
Nowadays, the pharmaceutical industry is facing an issue of poor aqueous solubility of drug. About 40% of the developing drugs and 60% of the directly synthesized drugs are poorly soluble in water. A poorly-aqueous-soluble drug shows poor bioavailability and high variable biological performance, especially administered through oral route, which is the ...
openaire   +2 more sources

A Compendium of Bioavailability Enhancement via Niosome Technology

Pharmaceutical Nanotechnology, 2023
Sumit Sharma
exaly  

Nanoemulsion: A Novel Drug Delivery Approach for Enhancement of Bioavailability

Recent Patents on Nanotechnology, 2020
Parijat Pandey, Harish Dureja
exaly  

Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions

Drug Delivery, 2021
Haowen Li, Jingxin Fu, Hui Ao
exaly  

Iron Bioavailability: Enhancers and Inhibitors

2022
Manju B. Reddy, Isaac Agbemafle, Seth Armah   +2 more
openaire   +1 more source