Results 51 to 60 of about 220,549 (336)

Public views on the donation and use of human biological samples in biomedical research: a mixed methods study [PDF]

, 2013
Objective A mixed methods study exploring the UK general public's willingness to donate human biosamples (HBSs) for biomedical research.<p></p> Setting Cross-sectional focus groups followed by an online survey.<p></p> ...
Clotworthy, M., Corfield, J., Hilton, S., Lewis, C., MaGee, C., Robertson, M.J., Stubbins, L.J.   +6 more
core   +1 more source

Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants

Occupational and Environmental Medicine, 2020
Objectives To investigate severe COVID-19 risk by occupational group. Methods Baseline UK Biobank data (2006–10) for England were linked to SARS-CoV-2 test results from Public Health England (16 March to 26 July 2020). Included participants were employed
M. Mutambudzi, Claire Niedwiedz, E. Macdonald, A. Leyland, F. Mair, Jana J. Anderson, C. Celis-Morales, J. Cleland, J. Forbes, J. Gill, C. Hastie, F. Ho, B. Jani, D. Mackay, B. Nicholl, C. O’Donnell, N. Sattar, P. Welsh, J. Pell, S. Katikireddi, E. Demou   +20 more
semanticscholar   +1 more source

Cancer bio-repository [PDF]

Iranian Journal of Colorectal Research, 2019
Background: Cancer research is highly dependent of large amount of data and high quality samples which can be provided by networks to enable large-scale multi-center research projects.
Shima Fakher, Seyed Vahid Hosseini, Mozhdeh Zamani, Leila Ghahramani, Pooneh mokaram Mokaram   +4 more
doaj   +1 more source

Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants [PDF]

, 2017
Background - Obesity is a multifactorial condition influenced by genetics, lifestyle and environment. Objective - To investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI)
Bailey, Mark E.S., Biello, Stephany M., Celis-Morales, Carlos, Gill, Jason M.R., Guo, Yibing, Llamas, Daniel, Lyall, Donald M., Mackay, Daniel F., Pell, Jill P., Steell, Lewis, Ward, Joey   +10 more
core   +1 more source

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

The journals of gerontology. Series A, Biological sciences and medical sciences, 2020
Background Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general older population) is unclear.
J. Atkins, Jane A. H. Masoli, J. Delgado, L. Pilling, Chia-Ling Kuo, G. Kuchel, D. Melzer   +6 more
semanticscholar   +1 more source

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank

bioRxiv, 2022
Phasing involves distinguishing the two parentally inherited copies of each chromosome into haplotypes. Here, we introduce SHAPEIT5, a new phasing method that quickly and accurately processes large sequencing datasets and applied it to UK Biobank (UKB ...
R. Hofmeister, D. Ribeiro, S. Rubinacci, O. Delaneau   +3 more
semanticscholar   +1 more source

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome [PDF]

, 2017
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of
Bateman, K., Chavada, Govindsinh, Cornblath, D. R., Cornblath, David R., Dardiotis, E., Faber, C. G., Feasby, T. E., Gorson, K. C., Gorson, Kenneth C., Harbo, T., Harbo, Thomas, Hartung, H. P., Hartung, H. P., Hartung, Hans Peter, Hughes, R. A.C., Hughes, Richard A.C., Illa, I., Islam, B., Islam, Z., Jacobs, B. C., Jacobs, B. C., Jacobs, B. C., Jacobs, Bart C., Kusunoki, S., Kusunoki, S., Kusunoki, Susumu, Lehmann, H. C., Mohammad, Q. D., Nobile-Orazio, E., Péréon, Y., Reddel, S. W., Reisin, R. C., Roodbol, J., Shahrizaila, N., van den Berg, B., van den Berg, B., van den Berg, Bianca, van den Bergh, P., van der Kooi, A. J., van Dijk, G. W., van Doorn, P. A., van Doorn, Pieter A., van Woerkom, M., Verboon, C., Verboon, C., Verboon, Christine, Visser, L. H., Wang, Y. Z., Willison, H. J., Willison, Hugh J.   +49 more
core   +3 more sources

Exome sequencing and characterization of 49,960 individuals in the UK Biobank

Nature, 2020
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world 1 .
C. V. van Hout, I. Tachmazidou, J. Backman, Joshua D Hoffman, Daren Liu, A. Pandey, C. Gonzaga‐Jauregui, S. Khalid, Bin Ye, N. Banerjee, Alexander Hanbo Li, C. O’Dushlaine, A. Marcketta, J. Staples, C. Schurmann, A. Hawes, E. Maxwell, Leland Barnard, Alexander E. Lopez, John Penn, L. Habegger, Andrew L Blumenfeld, X. Bai, S. O’Keeffe, A. Yadav, K. Praveen, Marcus Jones, W. Salerno, W. Chung, I. Surakka, C. Willer, K. Hveem, J. Leader, D. Carey, D. Ledbetter, L. Cardon, G. Yancopoulos, A. Economides, G. Coppola, A. Shuldiner, S. Balasubramanian, M. Cantor, M. Nelson, J. Whittaker, J. Reid, J. Marchini, J. Overton, R. Scott, G. Abecasis, L. Yerges-Armstrong, A. Baras   +50 more
semanticscholar   +1 more source

UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits

medRxiv, 2022
We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in UKB.
Deborah J Thompson, Daniel Wells, Saskia Selzam, Iliana Peneva, Rachel Moore, Kevin Sharp, William A. Tarran, Edward J. Beard, F. Riveros-Mckay, Duncan, Palmer, Priyanka Seth, James Harrison, M. Futema, G. McVean, V. Plagnol, P. Donnelly, M. Weale   +17 more
semanticscholar   +1 more source

Risk mapping for better governance in biobanking: the case of biobank.cy

Frontiers in Genetics
Introduction: Risk governance is central for the successful and ethical operation of biobanks and the continued social license for being custodians of samples and data. Risks in biobanking are often framed as risks for participants, whereas the biobank’s
Kaya Akyüz, Melanie Goisauf, Gillian M. Martin, Michaela Th. Mayrhofer, Stella Antoniou, Georgia Charalambidou, Constantinos Deltas, Constantinos Deltas, Apostolos Malatras, Gregory Papagregoriou, Charalambos Stefanou, Mariel Voutounou   +11 more
doaj   +1 more source