Results 51 to 60 of about 31,631 (243)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Lung cancer organoids: models for preclinical research and precision medicine

Frontiers in Oncology, 2023
Lung cancer is a malignancy with high incidence and mortality rates globally, and it has a 5-year survival rate of only 10%–20%. The significant heterogeneity in clinical presentation, histological features, multi-omics findings, and drug sensitivity ...
Yajing Liu, Yajing Liu, Yanbing Zhou, Pu Chen, Pu Chen   +4 more
doaj   +1 more source

Biobanks in Europe: Prospects for Harmonisation and Networking [PDF]

, 2010
Biobanks (i.e. the organised collections consisting of biological samples and associated data, have gained great significance for research and personalised medicine) are increasingly recognised as a crucial infrastructure for research.
A. SCERRI Christian, BRAUN Anette, DESCHÊNES Mylène, FORTIER Isabel, IBARRETA RUIZ Dolores, LAAGE-HELLMAN Jens, PACI Daniele, RIJKERS-DEFRASNE Sylvie, SCHULTE IN DEN BÄUMEN Tobias, ZIKA Eleni   +9 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Dwarna : a blockchain solution for dynamic consent in biobanking [PDF]

, 2019
Dynamic consent aims to empower research partners and facilitate active participation in the research process. Used within the context of biobanking, it gives individuals access to information and control to determine how and where their biospecimens ...
Desira, Maria, Ebejer, Jean Paul, Ellul, Bridget, Mamo, Nicholas, Martin, Gillian M.   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Evolutionary concepts in biobanking - the BC BioLibrary

Journal of Translational Medicine, 2009
Background Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens.
Hegele Richard G, Png Adrian, Giesz Sara C, Barnes Rebecca O, Wilson-McManus Janet E, Watson Peter H, Brinkman Jacquelyn N, Mackenzie Ian R, Huntsman David G, Junker Anne, Gilks Blake, Skarsgard Erik, Burgess Michael, Aparicio Samuel, McManus Bruce M   +14 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Oral and cardiometabolic health through the lens of biobanks and large-scale epidemiologic research

Frontiers in Oral Health
Oral diseases and cardiometabolic disorders are among the most prevalent non-communicable conditions worldwide and share common inflammatory, metabolic, and social determinants.
Nada Tawfig Hashim, Rasha Babiker, Vivek Padmanabhan, Md Sofiqul Islam, Sivan Padma Priya, Nallan C. S. K. Chaitanya, Riham Mohammed, Shahistha Parveen Dasnadi, Ayman Ahmed, Bakri Gobara Gismalla, Muhammed Mustahsen Rahman   +10 more
doaj   +1 more source

Biosamples as gifts? How participants in biobanking projects talk about donation. [PDF]

, 2015
Funded by National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust University of Oxford Oxford Biomedical Research Centre FellowshipPeer reviewedPublisher ...
Andrews, Barr, Cragg Ross Dawson, Dixon-Woods, Dixon-Woods, Gaskell, Haddow, Haimes, Hoeyer, Hoeyer, Kanellopoulou, Kaye, Laurie, Lenk, Lipworth, Locock, Manson, Mauss, Medical Research Council, Nuffield Council on Bioethics, OECD, People Science and Policy Ltd, Primary Care Reports, Scheper-Hughes, Seale, Solbakk, Titmuss, Tutton, Tutton, Waldby, Walsh, Widdows, Widdows   +32 more
core   +1 more source