Results 61 to 70 of about 31,338 (290)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Role of biobanks in the study of population immunity

Журнал инфектологии, 2018
Review focuses on estimation of population immunity and  effectiveness of vaccination against socially significant influenza  infection. Long-term observations of the population immunity,  including post-vaccine seroprevalence to influenza are an ...
O. S. Konshina, M. Yu. Eropkin, I. Yu. Nikonorov, M. G. Pozdnyakova   +3 more
doaj   +1 more source

Biosamples as gifts? How participants in biobanking projects talk about donation. [PDF]

, 2015
Funded by National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust University of Oxford Oxford Biomedical Research Centre FellowshipPeer reviewedPublisher ...
Andrews, Barr, Cragg Ross Dawson, Dixon-Woods, Dixon-Woods, Gaskell, Haddow, Haimes, Hoeyer, Hoeyer, Kanellopoulou, Kaye, Laurie, Lenk, Lipworth, Locock, Manson, Mauss, Medical Research Council, Nuffield Council on Bioethics, OECD, People Science and Policy Ltd, Primary Care Reports, Scheper-Hughes, Seale, Solbakk, Titmuss, Tutton, Tutton, Waldby, Walsh, Widdows, Widdows   +32 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Systematic review of birth cohort studies in South East Asia and Eastern Mediterranean regions [PDF]

, 2011
Few longitudinal studies of children have taken place in the developing world, despite child mortality being concentrated there. This review summarises the methodologies and main outcomes of longitudinal studies of pre-school children (0 to 59 months) in
Campbell, Harry, McKinnon, Rachel
core   +2 more sources

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. [PDF]

, 2017
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes.
Arias, Angelo, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A, Goldstein, Lawrence SB, Herrera, Cheryl, Matsui, Hiroko, Nathanson, Jason L, Panopoulos, Athanasia D, Reyna, Sol M, Williams, Roy, Woodruff, Grace, Yeo, Gene W   +12 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research [PDF]

, 2016
A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies.
Boomsma, D.I. (Dorret), Dietrich, J. (Joern), Duijn, C.M. (Cornelia) van, Esko, T. (Tõnu), Fortier, I. (Isabel), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Groop, L. (Leif), Harris, J.R. (Jennifer), Hastings, J. (Janna), Heggland, J. (Jon), Heikkinen, J. (Jani), Hottenga, J.J. (Jouke Jan), Hveem, K. (Kristian), Karvanen, J. (Juha), Klovins, J. (Janis), Krestyaninova, M. (Maria), Ladenvall, C. (Claes), Langhammer, A. (Arnulf), Litton, J.-E. (Jan-Eric), McCarthy, M.I. (Mark), Metspalu, A. (Andres), Ose, S. (Sandra), Palmgren, J. (Juni), Pedersen, N.L. (Nancy L.), Persson, M.-A. (Mats-Ake), Peters, A., Prokopenko, I. (Inga), Ried, J.S. (Janina), Ripatti, S. (Samuli), Rung, J. (Johan), Shen, H.-Y. (Huei-Yi), Spjuth, O. (Ola), Waldenberger, M. (Melanie), Willemsen, G. (Gonneke), Zaharenko, L. (Linda)   +35 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source