Results 41 to 50 of about 292,891 (317)

Michaelis-Menten at 100 and allosterism at 50: driving molecular motors in a hailstorm with noisy ATPase engines and allosteric transmission [PDF]

FEBS J. (Federation of European Biochem. Soc.), Special Issue: Enzyme Catalysis and Allostery: A Century of Advances in Molecular Understanding, vol.281, 601-611(2014), 2017
Cytoskeletal motor proteins move on filamentous tracks by converting input chemical energy that they derive by catalyzing the hydrolysis of ATP. The ATPase site is the analog of an engine and hydrolysis of ATP is the analog of burning of chemical fuel.
arxiv   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Development of predictive model for the fixed-bed column reactor

Applied Water Science, 2023
The present study aims at development of a mathematical model for the fixed-bed column adsorption that relates the reactor parameters with the breakthrough curve. Effects of operating parameters like bed height, flow rate, initial adsorbate concentration
Jyoti Singh, Santhosh Kumar Kumaresan, Sarvanshi Swaroop, Vishal Mishra   +3 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Blind source separation methods for deconvolution of complex signals in cancer biology [PDF]

2013. Biochemical and Biophysical Research Communications 430(3), 1182-1187, 2013
Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in molecular biology.
arxiv   +1 more source

Biochemical Properties of Tissue-Engineered Cartilage [PDF]

Journal of Craniofacial Surgery, 2014
Microtia is treated with rib cartilage sculpting and staged procedures; though aesthetically pleasing, these constructs lack native ear flexibility. Tissue-engineered (TE) elastic cartilage may bridge this gap; however, TE cartilage implants lead to hypertrophic changes with calcification and loss of flexibility.
John A. van Aalst, Robert G. Dennis, Roger J. Narayan, Matthew D. Skancke, Montserrat Caballero, Andrew K. Pappa, John P. Dahl   +6 more
openaire   +2 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Pitfalls in Early Bioprocess Development Using Shake Flask Cultivations

Engineering in Life Sciences
For about 100 years, the shake flask has been established for biotechnological cultivations as one of the most important cultivation systems in early process development.
Gesa Brauneck, Dominik Engel, Luca Antonia Grebe, Maximilian Hoffmann, Philipp Georg Lichtenberg, Anne Neuß, Marcel Mann, Jorgen Barsett Magnus   +7 more
doaj   +1 more source

Segregationally stabilised plasmids improve production of commodity chemicals in glucose-limited continuous fermentation

Microbial Cell Factories, 2022
Background The production of chemicals via bio-based routes is held back by limited easy-to-use stabilisation systems. A wide range of plasmid stabilisation mechanisms can be found in the literature, however, how these mechanisms effect genetic stability
James R. Allen, Mario A. Torres-Acosta, Naresh Mohan, Gary J. Lye, John M. Ward   +4 more
doaj   +1 more source

Effect of aprotic solvent on characteristics of Al2O3 ceramic hollow fiber substrates prepared by phase inversion for hydrogen permeation applications

Journal of Asian Ceramic Societies, 2022
The phase inversion procedure was used to prepare Al2O3 ceramic hollow fiber substrates (AlCHFS) utilizing the dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMAC), and 1-methyl-2-pyrrolidone (NMP) aprotic solvents.
Edoardo Magnone, Seung Hwan Lee, Min Chang Shin, Xuelong Zhuang, Jae Yeon Hwang, Jeong In Lee, Jung Hoon Park   +6 more
doaj   +1 more source