Results 51 to 60 of about 352,437 (243)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model. [PDF]
, 2017 In vitro experiments are essential to understand biological mechanisms; however, the gap between monolayer tissue culture and human physiology is large, and translation of findings is often poor.
Baar, Keith +2 more
core +2 more sources
Engineering BiologyFocus on engineering biology is at the forefront of the UK government's objectives, being one of their five critical technologies (the others being quantum technologies, artifical intelligence, semiconductors, and future telecommunications), with a ...
Amy Switzer, Laima Šusta, Paul Mines
doaj +1 more source
Optimization of L-lactic acid production by fermentation of Huaimi dregs
Biotechnology & Biotechnological Equipment, 2018 Utilization of waste dregs, e.g. Huaimi dregs, is an important issue. Huaimi is a traditional Chinese medicine and 20,000 tons of dregs are annually produced. This study optimized the production of L-lactic acid through solid-state fermentation of Huaimi
Jingsheng Zhang +5 more
doaj +1 more source
BMC Microbiology, 2023 Background The promising yet barely investigated anaerobic species Phocaeicola vulgatus (formerly Bacteroides vulgatus) plays a vital role for human gut health and effectively produces organic acids.
Laura Keitel +5 more
doaj +1 more source
Interaction and Mechanism of Probiotics with Gut Flora and Immune Regulation: A Review
Shipin gongye ke-ji, 2022 Probiotics play beneficial roles in improving the host intestinal microecological balance and improving the host health level and health state. It mainly affects the host health by regulating the intestinal microbiota and participating in the immune ...
Manyu TANG +8 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
An SFN-YOLO-based detection method for the fermentation stage in the anaerobic digestion process
iScienceSummary: Anaerobic digestion is an effective and low-carbon approach for biomass utilization and energy recovery. To accurately determine fermentation stages and enhance process control, this paper proposes an anaerobic digestion fermentation stage ...
Peng Liu +5 more
doaj +1 more source
Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&D
mAbs, 2020 This study aims to benchmark and analyze the process development and manufacturing costs across the biopharmaceutical drug development cycle and their contribution to overall research and development (R&D) costs.
Suzanne S. Farid +4 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source