Results 1 to 10 of about 139,196 (168)

Models for Oral Biology Research

Biomedicines, 2022
Oral biology is a scientific field that involves several disciplines, such as anatomy, cellular and molecular biology, genetics, microbiology, immunology, biochemistry, pharmacology, physiology and pathology [...]
Fernando Capela e Silva, Elsa Lamy, Paula Midori Castelo   +2 more
doaj   +1 more source

Yeast goes viral: probing SARS-CoV-2 biology using S. cerevisiae

Microbial Cell, 2022
The budding yeast Saccharomyces cerevisiae has long been an outstanding platform for understanding the biology of eukaryotic cells. Robust genetics, cell biology, molecular biology, and biochemistry complement deep and detailed genome annotation, a ...
Brandon Ho, Raphael Loll-Krippleber, Grant W. Brown   +2 more
doaj   +1 more source

Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL

STAR Protocols, 2022
Summary: Mitochondrial polymerase gamma (PolγA) is the only replicative polymerase in mitochondria. To determine PolγA ubiquitylation in cells, Flag-PolγA and MITOL are overexpressed, and subsequently the immunoprecipitated Flag-PolγA is checked for ...
Mansoor Hussain, Shabnam Saifi, Aftab Mohammed, Sagar Sengupta   +3 more
doaj   +1 more source

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family [PDF]

Biochemical Journal, 2009
RGMs (repulsive guidance molecules) comprise a recently discovered family of GPI (glycosylphosphatidylinositol)-linked cell-membrane-associated proteins found in most vertebrate species. The three proteins, RGMa, RGMb and RGMc, products of distinct single-copy genes that arose early in vertebrate evolution, are ∼40–50% identical to each other in ...
Christopher J, Severyn, Ujwal, Shinde, Peter, Rotwein   +2 more
openaire   +2 more sources

Whole genome sequencing facilitates intragenic variant interpretation following modifier screening in C. elegans

BMC Genomics, 2021
Background Intragenic modifiers (in-phase, second-site variants) are known to have dramatic effects on clinical outcomes, affecting disease attributes such as severity or age of onset. However, despite their clinical importance, the focus of many genetic
Francesca Jean, Susan Stasiuk, Tatiana Maroilley, Catherine Diao, Andrew Galbraith, Maja Tarailo-Graovac   +5 more
doaj   +1 more source

SAPK10-Mediated Phosphorylation on WRKY72 Releases Its Suppression on Jasmonic Acid Biosynthesis and Bacterial Blight Resistance

iScience, 2019
Summary: Bacterial blight caused by the infection of Xanthomonas oryzae pv. oryzae (Xoo) is a devastating disease that severely challenges the yield of rice. Here, we report the identification of a “SAPK10-WRKY72-AOS1” module, through which Xoo infection
Yuxuan Hou, Yifeng Wang, Liqun Tang, Xiaohong Tong, Ling Wang, Lianmeng Liu, Shiwen Huang, Jian Zhang   +7 more
doaj   +1 more source

Deciphering complex genome rearrangements in C. elegans using short-read whole genome sequencing

Scientific Reports, 2021
Genomic rearrangements cause congenital disorders, cancer, and complex diseases in human. Yet, they are still understudied in rare diseases because their detection is challenging, despite the advent of whole genome sequencing (WGS) technologies.
Tatiana Maroilley, Xiao Li, Matthew Oldach, Francesca Jean, Susan J. Stasiuk, Maja Tarailo-Graovac   +5 more
doaj   +1 more source

Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation

iScience, 2019
Summary: Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, in antiviral immunity remains poorly defined.
Jian Li, Chunmei Ma, Fei Long, Dongxue Yang, Xue Liu, Yingchao Hu, Chunyan Wu, Bingwei Wang, Min Wang, Yunzi Chen, Genyan Liu, Paul N. Moynagh, Jiawei Zhou, Tao Peng, Shuo Yang   +14 more
doaj   +1 more source

Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo

BMC Infectious Diseases, 2021
Background The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution.
Akouélé P. Kuassi-Kpede, Essolakina Dolou, Théodora M. Zohoncon, Ina Marie Angèle Traore, Gnatoulma Katawa, R. Alice Ouedraogo, Esther Mah Traore, Prosper Bado, T. Clarisse Ouedraogo, Florencia Wendkuuni Djigma, Simplice Damintoti Karou, Jacques Simpore   +11 more
doaj   +1 more source

Peroxisomes: biochemistry, molecular biology and genetic diseases-a video programme for teaching students [PDF]

Biochemical Education, 2000
Abstract Peroxisome proliferation in rodent liver is a good biochemical marker of toxicology for several classes of xenobiotics, including fibrates; phthalates and adipates; or chlorophenoxy-acetate, a herbicide. Research in peroxisomes provides a good example of the integration of fields related to basic sciences and biomedical and industrial health.
Norbert Latruffe, Shawn J. Hassell
openaire   +1 more source